Lec 3 - Lipoproteins

Question 1

lipoprotein particle has a blank outer and blank inner

Answer 1

hydrophilic, hydrophobic

Question 2

lipoproteins also have one or more blank but the exact type can vary among particles

Answer 2

apoproteins

Question 3

the part of cholesterol that is hydrophilic and can be on the outside of lipoprotein particle

Answer 3

OH group

Question 4

these are made in the intestine from fats absorbed in the diet

Answer 4

chylomicrons

Question 5

chylomicrons contain mainly blank with some blank

Answer 5

triglycerides, cholesterol

Question 6

chylomicrons are broken down by blank to yield fatty acids that are taken up by the liver

Answer 6

lipoprotein lipase

Question 7

these are made in the liver from fats from both diet and synthesized by liver

Answer 7

vldl

Question 8

vldl contain mostly blank with some blank

Answer 8

triglycerides, cholesterol

Question 9

vldl are broken down by lpl to yield these

Answer 9

free fatty acids AND intermediate density lipoproteins

Question 10

these are derived from intermediate density lipoproteins

Answer 10

LDL

Question 11

LDL have mostly blank with some blank

Answer 11

cholesterol, triglycerides

Question 12

LDL can be taken up by the liver or by other tissues while things like chylomicrons and VLDL can enter blank

Answer 12

bloodstream

Question 13

most common source of cholesterol to the body

Answer 13

LDL

Question 14

LDL receptors bind to the blank protein of the LDL particle

Answer 14

ApoB-100 (ON TEST)

Question 15

internalization of LDL particles occurs at blank

Answer 15

clathrin coated pits

Question 16

LDL components are hydrolyzed after fusion with a blank

Answer 16

lysosome

Question 17

increased cellular cholesterol levels inhibit transcription of the blank as well as the blank

Answer 17

HMG CoA Reductase gene, LDL receptor

Question 18

LDL is paired with blank

Answer 18

ACAT

Question 19

cholesterol picked up by HDL is esterified by blank

Answer 19

LCAT

Question 20

HDL returns to liver where it is blank

Answer 20

excreted

Question 21

main job of LDL and HDL

Answer 21

transport cholesterol

Question 22

LDL transports cholesterol to blank

Answer 22

tissues

Question 23

HDL transports cholesterol to blank

Answer 23

liver (TEST QUESTION)

Question 24

bile salts are bile acids conjugated to one of these two amino acids

Answer 24

glycine, taurine

Question 25

key reaction of synthesis of bile acids and bile salts is the blank of carbon 7 of cholesterol

Answer 25

hydroxylation

Question 26

in the intestines, bacteria convert bile salts to blank by removing glycine and taurine

Answer 26

secondary bile acids

Question 27

there is no requirement for cholesterol in the blank

Answer 27

diet

Question 28

excess cholesterol can lead to producing these

Answer 28

gall stones

Question 29

cholesterol is needed to make these hormones

Answer 29

steroid

Question 30

statin drugs like lipitor inhibit cholesterol synthesis by inhibiting blank

Answer 30

HMG CoA reductase

Question 31

familial hypercholesterolemia is caused by mutations in blank receptor

Answer 31

LDL

Question 32

lipoproteins are used for blank transportation in the blood

Answer 32

cholesterol