Lec 1

Question 1

three classes of membrane lipids

Answer 1

phospholipids, sphingolipids, sterols

Question 2

lipids are soluble or insoluble

Answer 2

insoluble

Question 3

backbone of phospholipid

Answer 3

glycerol

Question 4

phosphoglycerides have blank fatty acids attached by a blank linkage to glycerol and a phosphorylated alcohol

Answer 4

two, ester

Question 5

synthesis of phosphoglycerides is a complex pathway involving activation of intermediates using the ribonucleotide blank

Answer 5

cytidine triphosphate

Question 6

starting point of phosphoglyceride biosynthesis

Answer 6

glycerol 3 phosphate

Question 7

slide about stuff to remember about phosphoglycerate synthesis… hugely important

Answer 7

ok

Question 8

phosphoglyceride lipids that are a component of surfactant in the lungs which keeps the alveoli open between breaths

Answer 8

dipalmitoyl phosphatidylcholine

Question 9

special phosphoglyceride lipid that is a major mediator of hypersensitivity and acute inflammatory reactions like anaphylactic shock and sepsis

Answer 9

platelet activating factor

Question 10

a phospholipid that is not a phosphoglyceride because it doesnt have glycerol

Answer 10

sphingomyelin

Question 11

backbone of sphinomyelin

Answer 11

serine

Question 12

2 fatty acids on serine is called a blank

Answer 12

ceramide

Question 13

key points of sphingolipid biosynthesis slide … very important!

Answer 13

ok

Question 14

sphingolipids have blank fatty acid chains compared to phosphoglycerides

Answer 14

longer (18-24)

Question 15

sphingolipids and ceramides have special hydrogen bonding properties that allow them to blank with other membrane molecules like cholesterol

Answer 15

associate

Question 16

sphingolipids are important for blank and blank including blood transfusions because they help to show immune system the difference between self and non self tissues

Answer 16

organ, tissue transplants

Question 17

most well studied sphingolipidosis caused by mutations in an enzyme

Answer 17

tay sachs disease

Question 18

phosphlipid containing this is important in signaling and intracellular communication

Answer 18

arachidonic acid

Question 19

arachidonic acid is a blank fatty acid with a double bond at these positions

Answer 19

polyunsaturated 6,9,12,15

Question 20

blank are derivatives of arachidonic acid that are secreted by cells and act on other cells in the immediate vicinity

Answer 20

eicosanoids

Question 21

blood clots, smooth muscle contraction, fever, pain sensitivity, swelling are all things done by blank

Answer 21

eicosanoids

Question 22

arachidonic acid is in a blank conformation

Answer 22

folded

Question 23

arachidonic acid is involved in making these lipids

Answer 23

eicosanoids

Question 24

enzyme that catalyzes first step in pathway of making prostaglandins

Answer 24

cox

Question 25

cox 1 is a blank form of the enzyme

Answer 25

constitutive

Question 26

cox 2 is a blank form of the enzyme

Answer 26

inducible

Question 27

essential fatty acid that has double bonds between 3 and 4th carbons

Answer 27

omega 3 fatty acid

Question 28

essential fatty acid that has double bond between 6 and 7th carbon atoms

Answer 28

omega 6 fatty acid

Question 29

omega 3 and 6 fatty acids are released by activity of blank enzyme

Answer 29

PLA2

Question 30

proinflammatory blank are elevated in oral inflammatory states like periodontitis

Answer 30

eicosanoids

Question 31

membranes have blank heads and blank tails

Answer 31

hydrophilic, hydrophobic