Lec 1 Flashcards
three classes of membrane lipids
phospholipids, sphingolipids, sterols
lipids are soluble or insoluble
insoluble
backbone of phospholipid
glycerol
phosphoglycerides have blank fatty acids attached by a blank linkage to glycerol and a phosphorylated alcohol
two, ester
synthesis of phosphoglycerides is a complex pathway involving activation of intermediates using the ribonucleotide blank
cytidine triphosphate
starting point of phosphoglyceride biosynthesis
glycerol 3 phosphate
slide about stuff to remember about phosphoglycerate synthesis… hugely important
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phosphoglyceride lipids that are a component of surfactant in the lungs which keeps the alveoli open between breaths
dipalmitoyl phosphatidylcholine
special phosphoglyceride lipid that is a major mediator of hypersensitivity and acute inflammatory reactions like anaphylactic shock and sepsis
platelet activating factor
a phospholipid that is not a phosphoglyceride because it doesnt have glycerol
sphingomyelin
backbone of sphinomyelin
serine
2 fatty acids on serine is called a blank
ceramide
key points of sphingolipid biosynthesis slide … very important!
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sphingolipids have blank fatty acid chains compared to phosphoglycerides
longer (18-24)
sphingolipids and ceramides have special hydrogen bonding properties that allow them to blank with other membrane molecules like cholesterol
associate
sphingolipids are important for blank and blank including blood transfusions because they help to show immune system the difference between self and non self tissues
organ, tissue transplants
most well studied sphingolipidosis caused by mutations in an enzyme
tay sachs disease
phosphlipid containing this is important in signaling and intracellular communication
arachidonic acid
arachidonic acid is a blank fatty acid with a double bond at these positions
polyunsaturated 6,9,12,15
blank are derivatives of arachidonic acid that are secreted by cells and act on other cells in the immediate vicinity
eicosanoids
blood clots, smooth muscle contraction, fever, pain sensitivity, swelling are all things done by blank
eicosanoids
arachidonic acid is in a blank conformation
folded
arachidonic acid is involved in making these lipids
eicosanoids
enzyme that catalyzes first step in pathway of making prostaglandins
cox
cox 1 is a blank form of the enzyme
constitutive
cox 2 is a blank form of the enzyme
inducible
essential fatty acid that has double bonds between 3 and 4th carbons
omega 3 fatty acid
essential fatty acid that has double bond between 6 and 7th carbon atoms
omega 6 fatty acid
omega 3 and 6 fatty acids are released by activity of blank enzyme
PLA2
proinflammatory blank are elevated in oral inflammatory states like periodontitis
eicosanoids
membranes have blank heads and blank tails
hydrophilic, hydrophobic
