Lec 2 Review of brain histology Flashcards

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1
Q

Where in the neuron does the action potential initiate?

A

the spike initiaion zone in the nerve cell body (soma) near the axon hillock

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2
Q

What are boutons?

A

swellings at the ends of axon terminal

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3
Q

What is a telodendron?

A

the entire array of terminals for one axonal process

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4
Q

What are neruonal processes?

A

non-specifically refer to axons and dendrites

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5
Q

What is structure of multipolar neurons?

A
  • 3-5 primary dendrites coming off cell body
  • axon emerges from axon hillock
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6
Q

Where do you find multipolar neurons?

A

through the CNS

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7
Q

What is structure of bipolar neurons?

A
  • single process
  • cell body located directly along the course
  • distal extension is dendrite, proximal (directed toward CNS) is axon
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8
Q

Where do you find bipolar neruons?

A
  • retina
  • in clusers of cell bodies (ganglia) of vestibular and auditory cranial nerves
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9
Q

What is structure of unipolar neurons?

A
  • single process extends proximally and distally from a short segment that connect it to the cell body
  • both parts of process technically called neurites (or distal = dendrite, proximal = axon)
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10
Q

Where do you find unipolar neurons?

A

sensory ganglia in PNS

notably in dorsal root ganglia

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11
Q

What is structure of pyramidal cells?

A
  • pear shaped soma, several dendrites

large, highly branched dendrite from apex of soma called apical dendrite

  • axon from base of the cell body
  • have dendritic spines
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12
Q

What is function of dendritic spines?

A
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13
Q

What are granule cells? structure?

A
  • smaller, star shaped (stellate)
  • dendritic tree radiates out in all directiosn from the soma
  • provide much of local (regional) info processing)
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14
Q

What are the 3 different types of neurons as classified by length of axon?

A
  • projection clels
  • interneurons
  • amacrine cells
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15
Q

What are projection cells?

A
  • neurons with long axons
  • axons extend long distance, send neural signal from one region of nervous system to another
  • long axons sometimes branch into: 1. main axon that projects to chief target site, 2. axon collateral that projects to another far location
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16
Q

What are interneurons?

A
  • neurons with short axons

their axons remian within the region of cell’s dendritic field

  • provide local synaptic interactions and feedback
  • many are inhibitory
17
Q

What are amacrine cells? Where are they found?

A
  • axon-less neurons
  • found in retina and olfactory bulb
18
Q

What is the neuromuscular junction?

A
  • specialized version of a synapse
  • motor neuron + NMJ forms motor end plate consisting of enlarged axon terminal with synaptic vesicles, junctional folds, enlarged synaptic clefs, muscle sole plate
19
Q

What are the 3 general neruonal cell death pathways?

A
  • necrosis
  • apoptosis
  • autophagy
20
Q

What factors lead to selective vulnerability?

A
  • cytoarchitecture
  • physiology/metabolism
  • regional/network associations
  • blood supply
21
Q

In what diseases is prolonged microglia activation thought to play a role in neurodegeneration?

A
  • alzheimers
  • parkinsons
  • viral (HIV, HSV) infections
  • bacterial (streptococcus pneumoniae) infections
  • parasitic (plasmodium falciparum) infections
22
Q

What are two types of lower motor neuron diseases?

A

ALS, polio

23
Q

What are two subtypes of astrocytes?

A

fibrous (found in white matter)

protoplasmic (found in gray matter)

24
Q

Why do myelinated axons appear white?

A

myelin has high lipid content

25
Q

What makes of gray vs white matter?

A

white matter contains myelinated fiber tracts

gray matter contains high concentrations of cell bodies

26
Q

What type of disease is multiple sclerosis?

A

A demyelinating disease

27
Q

What is schwannoma?

A

a benign encapsulated tumor originating from schwann cells