LEC 2 Flashcards
what are meninges
membranes that cover brain and spinal cord
how many meninges
3 (dura, arachnoid, pia)
where is CSF located
arachnoid
what should CSF not have
microorganisms
what is gram morphology of N.m
gram neg diplococcus
what does N.m have around outer cell wall
capsule made of polysaccharides
what is mode of transmission
droplet
what is droplet transmission
large mucous molecules expelled through cough + sneeze
VIRULENCE FACTORS where is endotoxin / lipid A located
cell wall
VIRULENCE FACTORS what does endotoxin of N.m cause (4)
- blood clotting
- DIC
- hemorrhage
- shock
VIRULENCE FACTORS what does hemorrhage lead to
- petechiae
2. purpura
VIRULENCE FACTORS what are petechiae
small purple spots
VIRULENCE FACTORS what are purpura
large purple spot
VIRULENCE FACTORS what does capsule of N.m cause
inactivation of WBC trying to phagocytize it
VIRULENCE FACTORS what does inactivation of WBC by N.m cause
N.m replication in CSF
VIRULENCE FACTORS what does N.m replication in CSF cause
- bacteria die
2. bacteria release endotoxin
VIRULENCE FACTORS what is another name for N.m
meningococcus
what 2 diseases can meningococcus cause
- meningococcal meningitis
2. meningococcal sepsis
what is meningococcal meningitis
inflammation of meninges
what is meningococcal sepsis
replication of bacteria in blood
what kind of sepsis is meningococcal sepsis
gram neg
what does gram neg sepsis mean
endotoxin involved
SYMPTOMS what are symptoms of meningococcal meningitis (5)
- fever
- petechiae
- headache
- photosensitivity
- stiff neck
SYMPTOMS what are symptoms of meningococcal sepsis (5)
- fever
- petechiae
- shock
- DIC
- hemorrhage
