LEC 2 Flashcards

1
Q

what are meninges

A

membranes that cover brain and spinal cord

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2
Q

how many meninges

A

3 (dura, arachnoid, pia)

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3
Q

where is CSF located

A

arachnoid

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4
Q

what should CSF not have

A

microorganisms

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5
Q

what is gram morphology of N.m

A

gram neg diplococcus

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6
Q

what does N.m have around outer cell wall

A

capsule made of polysaccharides

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7
Q

what is mode of transmission

A

droplet

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8
Q

what is droplet transmission

A

large mucous molecules expelled through cough + sneeze

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9
Q

VIRULENCE FACTORS where is endotoxin / lipid A located

A

cell wall

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10
Q

VIRULENCE FACTORS what does endotoxin of N.m cause (4)

A
  1. blood clotting
  2. DIC
  3. hemorrhage
  4. shock
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11
Q

VIRULENCE FACTORS what does hemorrhage lead to

A
  1. petechiae

2. purpura

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12
Q

VIRULENCE FACTORS what are petechiae

A

small purple spots

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13
Q

VIRULENCE FACTORS what are purpura

A

large purple spot

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14
Q

VIRULENCE FACTORS what does capsule of N.m cause

A

inactivation of WBC trying to phagocytize it

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15
Q

VIRULENCE FACTORS what does inactivation of WBC by N.m cause

A

N.m replication in CSF

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16
Q

VIRULENCE FACTORS what does N.m replication in CSF cause

A
  1. bacteria die

2. bacteria release endotoxin

17
Q

VIRULENCE FACTORS what is another name for N.m

A

meningococcus

18
Q

what 2 diseases can meningococcus cause

A
  1. meningococcal meningitis

2. meningococcal sepsis

19
Q

what is meningococcal meningitis

A

inflammation of meninges

20
Q

what is meningococcal sepsis

A

replication of bacteria in blood

21
Q

what kind of sepsis is meningococcal sepsis

A

gram neg

22
Q

what does gram neg sepsis mean

A

endotoxin involved

23
Q

SYMPTOMS what are symptoms of meningococcal meningitis (5)

A
  1. fever
  2. petechiae
  3. headache
  4. photosensitivity
  5. stiff neck
24
Q

SYMPTOMS what are symptoms of meningococcal sepsis (5)

A
  1. fever
  2. petechiae
  3. shock
  4. DIC
  5. hemorrhage
25
Q

what happens as soon as CSF and blood taken

A

administration of empirical antibiotic

26
Q

what is empirical antibiotic

A

best guess antibiotic before culture confirmation

27
Q

what is purpose of culturing bacteria

A

used for antibiotic testing

28
Q

what are 3 types of vaccines

A
  1. polysaccharide
  2. conjugate
  3. type B
29
Q

what is polysaccharide vaccine

A

antibodies made for polysaccharide (of capsule)

30
Q

what is conjugated vaccine

A

antibodies for polysaccharide + immunogenic protein

31
Q

what is type B vaccine

A

antibodies for proteins in cell wall of B serotype

32
Q

what to offer contacts of those that were infected

A

prophylactic / preventative antibiotic

33
Q

what is purpose of antibiotic if vaccine administered

A

vaccine takes 2 weeks to become effective