Lec 17/18 Flashcards
Monoclonal antibodies were the earliest approved antibodies for cancer. They are used for cancer treatment but do not elicit a “therapeutic” response from the immune system. Which type of therapy treatment are monoclonal antibodies considered to be?
a. Immunotherapy
b. Targeted therapy
c. Oncotherapy
d. Tumor-agnostic therapy
b - Monoclonal antibodies are considered targeted therapy treatment because they are drugs which directly target cancer cells without affecting normal cells
what does Rituximab bind to on B cells?
what does it treat?
CD20
B cell Non-Hodgkin lymphomas
what does Alemtuzumab target on lymphocytes?
what does it treat?
CD52
B-cell chronic lymphocytic leukemia
what does Brentuximab target?
What does it treat?
CD30
Hodgkin lymphoma and T cell non-Hodgkin lymphoma
what does Trastuzumab target?
how does it work?
HER-2 overexpression in breast and stomach cancers
anti-HER2 antibodies inhibit HER2-mediated signaling in cancer cells to prevent growth
what does Tositumomab I-131 target?
what does it treat?
CD20
non-Hodgkin’s lymphomas
what does Ipilimumab target on T-cell? what does it do?
CTLA-4 to prevent the inhibition of T-cell response to tumors
how do interferons work for cancer therapy?
they help the immune system fight cancer and may slow growth of cancer cells
how do interleukins work for cancer therapy?
they help the immune system produce cells to destroy cancer
initial exposure to an allergen leads to activation of allergen specific ____ cells and ___ synthesis
TH2 IgE
TH2 secretion of IL-5 causes?
eosinophil activation
TH2 secretion of IL-4, and IL-13 causes?
Memory B cell to produce IgE
TH2 secretion of IL-9 and IL-13 causes?
allergic rhinitis and asthma
TH2 secretion of IL-4, IL-13, SCF, and KIT causes?
basophils to enter tissues/ mast cell and basophil degranulation
TH2 secretion of IL-4, IL-13, and CCL5 causes?
increased endothelial cell adhesion
TH2 secretion of IL-13 causes?
smooth muscle cell activation and contraction
TH2 binding to DC causes?
T-cell activation and proliferation
TH1 secretion of IFNy, TNF, and CD95L causes?
atopic dermatitis
T/F The induction of peripheral T cell tolerance and promotion of the formation of regulatory T-cells are key mechanisms in allergen-SIT
True
T/F Formation of non-inflammatory antibodies particularly IgG4 is induced by IL-10
True
how does cromolyn help treat asthma?
inhibits mast cell degranulation (mast cell stabilizer)
