Lec 17/18 Flashcards

1
Q

Monoclonal antibodies were the earliest approved antibodies for cancer. They are used for cancer treatment but do not elicit a “therapeutic” response from the immune system. Which type of therapy treatment are monoclonal antibodies considered to be?

a. Immunotherapy
b. Targeted therapy
c. Oncotherapy
d. Tumor-agnostic therapy

A

b - Monoclonal antibodies are considered targeted therapy treatment because they are drugs which directly target cancer cells without affecting normal cells

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2
Q

what does Rituximab bind to on B cells?

what does it treat?

A

CD20

B cell Non-Hodgkin lymphomas

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3
Q

what does Alemtuzumab target on lymphocytes?

what does it treat?

A

CD52

B-cell chronic lymphocytic leukemia

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4
Q

what does Brentuximab target?

What does it treat?

A

CD30

Hodgkin lymphoma and T cell non-Hodgkin lymphoma

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5
Q

what does Trastuzumab target?

how does it work?

A

HER-2 overexpression in breast and stomach cancers

anti-HER2 antibodies inhibit HER2-mediated signaling in cancer cells to prevent growth

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6
Q

what does Tositumomab I-131 target?

what does it treat?

A

CD20

non-Hodgkin’s lymphomas

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7
Q

what does Ipilimumab target on T-cell? what does it do?

A

CTLA-4 to prevent the inhibition of T-cell response to tumors

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8
Q

how do interferons work for cancer therapy?

A

they help the immune system fight cancer and may slow growth of cancer cells

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9
Q

how do interleukins work for cancer therapy?

A

they help the immune system produce cells to destroy cancer

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10
Q

initial exposure to an allergen leads to activation of allergen specific ____ cells and ___ synthesis

A

TH2 IgE

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11
Q

TH2 secretion of IL-5 causes?

A

eosinophil activation

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12
Q

TH2 secretion of IL-4, and IL-13 causes?

A

Memory B cell to produce IgE

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13
Q

TH2 secretion of IL-9 and IL-13 causes?

A

allergic rhinitis and asthma

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14
Q

TH2 secretion of IL-4, IL-13, SCF, and KIT causes?

A

basophils to enter tissues/ mast cell and basophil degranulation

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15
Q

TH2 secretion of IL-4, IL-13, and CCL5 causes?

A

increased endothelial cell adhesion

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16
Q

TH2 secretion of IL-13 causes?

A

smooth muscle cell activation and contraction

17
Q

TH2 binding to DC causes?

A

T-cell activation and proliferation

18
Q

TH1 secretion of IFNy, TNF, and CD95L causes?

A

atopic dermatitis

19
Q

T/F The induction of peripheral T cell tolerance and promotion of the formation of regulatory T-cells are key mechanisms in allergen-SIT

A

True

20
Q

T/F Formation of non-inflammatory antibodies particularly IgG4 is induced by IL-10

A

True

21
Q

how does cromolyn help treat asthma?

A

inhibits mast cell degranulation (mast cell stabilizer)