Cytokines and their functions Flashcards
IL-1beta:
family
what cells distribute them (source)
function
IL-1 macrophages and monocytes - pro-inflammation - proliferation - apoptosis - differentiation
IL-4
family
what cells distribute them (source)
function
IL-4 T helper cells - anti-inflammation - T-cell and B-cell proliferation - B-cell differentiation
IL-6
family
what cells distribute them (source)
function
IL-6 macrophages, T cells - pro-inflammation - differentiation - cytokine production
IL-10
family
what cells distribute them (source)
function
IL-10
Monocytes, T cells, B cells
- Anti-inflammation
- inhibition of pro-inflammatory cytokines
IL-12
family
what cells distribute them (source)
function
IL-12 dendritic cells, macrophages, neutrophils - pro-inflammation - cell differentiation - activates NK cells
TNF-aplha
family
what cells distribute them (source)
function
TNF macrophages, NK cells, CD4+ lymphocytes - pro-inflammation - cytokine production - cell proliferation - apoptosis - anti-infection
IFN-y
family
what cells distribute them (source)
function
INF
T cells, NK cells
- pro-inflammation
- innate, adaptive immunity anti-viral
TH1 cell:
signature cytokine(s)
immune reactions
defends against?
IFN-y
macrophage activation, IgG production
intracellular microbes
TH2 cell:
signature cytokine(s)
immune reactions
defends against?
IL-4, IL-5, IL-13
mast cell and eosinophil activation, IgE production, macrophage activation
helminthic (infectious) parasites
TH17 cell
signature cytokine(s)
immune reactions
defends against?
IL-17A, IL-17F, IL-22
neutrophilic and monocytic inflammation
extracellular bacteria/fungi
T regulatory cell
signature cytokine(s)
immune reactions
defends against?
TGF-b, IL-10, Foxp3
inhibition of some T cell subsets, helps in IgA production
defense unkown
IL-2
what cells distribute them (source)
function
T cells
- cell proliferation
