Learning and memory 2 Flashcards
where do neural mechansism for long term explicit memory occur?
the hippocampus
what is the main LTP pathway
Schaffer collateral
what are the main postsynaptic receptors involved in LTP
AMPA
NMDA
what is Donald Hebbs rule
neurons that fire together, wire together
what are the cells of the mossy fibre pathway
dendate granules and CA3 pyrimidial cells
what does the mossy fibre pathway show us?
that not NMDA dependent
instead it requires activation of protein kinase A
what is the main feature of LTP in the mossy fibre pathway
it is non associative meaning that only requires presynaptic changes
what are the two phases of LTP
early and late
what does late LTP have that early phase doesnt
protein transcription
what is the signalling cascade which leads to protein transcription in late phase LTP
calmodulin-> cAMP-> PKA->adenylate cyclase-> CREB-1->mRNA transcriptioni
how do we prove that late phase LTP has protein transcription
with use of anisomyosin to early and late phases, only affects late phase
what is one experiment used to measure LTP and behaviour
morris water maze using rats to find platform
which lesions leads to inability of rats to complete morris water maze
knockout of NMDARs in Ca1
what is long term depression
sustained reduction in synaptic strength
what is ant-hebbian learning
weakening of synapses that do not contribute to the firing of a post synaptic cells
