Diversity of ion channels

Question 1

what are the six assumptions of HH model of action potentials

Answer 1

all currents in AP due to electrochemical gradients
na and k flow through separate channels
each channel is open or shut
each channel has one or more gates
each gate obeys first order kinetics with voltage dependent rate constants

Question 2

what does voltage dependence mean

Answer 2

gates open and close at random but probability of a gate being open or closed is voltage dependent

Question 3

what are the two na channel gates

Answer 3

activation gate (m)
inactivation gate (h)

Question 4

describe sodiums m gate

Answer 4

very fast

3 per channel in a series

Question 5

describe sodium h gates

Answer 5

slightly slower than m

only one per channe

Question 6

what is k channel gate

Answer 6

activation gate (n)

Question 7

describe potassiums n gate

Answer 7

slowest response

4 per channel in a series

Question 8

what is the rule for channels conducting

Answer 8

all gates must be open for conductance