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Y3: PN3313 > Chemical Synapse 1 > Flashcards

Chemical Synapse 1 Flashcards

1
Q

what is a feature of temporal summation

A

2nd PSP comes before the 1st PSP decays completed and 2nd PSP rides on back of first one

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2
Q

what determines temporal summation

A

postsynaptic time constant

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3
Q

what is a feature of spatial summation

A

arrival of 2nd input coincides that of the 1st

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4
Q

what are the two types of short term plasticity

A

faciliation

anti facilitaiton

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5
Q

what is a feature of facilitation

A

2nd PSP is bigger

2nd comes after 1st decays fully

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6
Q

what is the mechanism of facilitation

A

accumulation of ca2+ in presynaptic terminal
increase in releasable vesicles through auto-receptor
calcium channel facilitation

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7
Q

what are three characteristics of anti-facilitation

A

depression, decrement, fatigue

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8
Q

what is a feature of anti-facilitation

A

2nd PSP is smaller than the 1st PSP

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9
Q

what are the mechanisms of anti-facilitation

A

depletion of vesicles in presynaptic axon terminal
desensitisation of postsynaptic receptors
saturation of postsynaptic receptors
activation of autoreceptors

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10
Q

what are two forms of long term plasticity

A

ltp- long term potentiation

ltd- long term depression

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11
Q

where is LTP most commonly found

A

in the hippocampyus

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12
Q

where does LTP form

A

hebbian synapses

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13
Q

what is the main feature of LTP

A

after simultaneous firing, pre and post synaptic neurons have enhanced EPSPS

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14
Q

what is a model of LTP induction

A

schaffer collateral

ca1 pyramidial synapse

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15
Q

what is the main channel assoiated with LTP

A

NMDAR which blocked by Mg2+

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16
Q

what are the two phase of LTP

A

early and late

17
Q

what is early phase ltp

A

ehancement of transmitter release, new AMPARs in postynsaptic membrane
increase glutamate affinity

18
Q

what is late phase LTP

A

cAMP and cAMP kinase activated
CREB-1 protein phosphorylation
gene transcriptioin
new synapse

19
Q

what is the feature of LTP at non hebbian synapses

A

LTP doesnt involve co activation of pre and post synaptic neurons

20
Q

what is the mechanism of LTP at non hebbian synapses

A

activation of g proteins and protein kinases

21
Q

what is the main feature of ltd

A

synaptic transmission becomes weaker over time

22
Q

what is the mechanisms of LTD

A

at cerbrall parallel fibre synapse

internalisation and desensitsation of AMPARs

Y3: PN3313 (23 decks)

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