lead final Flashcards
n Essential metals
– trace amount for life,
e.g. Cu, Fe and Zn
n Non essential metals
- no known biological
functions,
e.g. Cd, Pb, Hg
Metal pollution: why is it a problem?
Metals can neither be created nor destroyed
n Problematic environmental contaminants
n Metals are naturally occurring
n Anthropogenic activities increase metal exposure to
organisms either because:
n Metals are moved from biologically inaccessible to
accessible compartments in the biospheres
n Form of the metal is changed to more bioavailable or
toxic form (e.g., free ions)
anthropogenic sources
from humans, industries
What is lead (Pb)?
A soft, heavy, bluish-gray metal found in the earth’s crust n One of the seven ancient metals known to humans (Ag, Au, Cu, Fe, Hg, Pb, Sn) n Ductile and pliable, making it easy to use n No biological function, but mimics Calcium (Ca) and Iron (Fe)
pb is similar to what element
to calcium- therefore absorbed just like it
calcium analog
what are the 2 main antropogenic sources
fossil fuel combustion
and mining
How we might be exposed to Pb?
paint, in soil, gas, dust, water, workplace
Lead paints are still being used in many countries
- a major source of human exposure to lead
cool story bro
Routes of Pb exposure to humans
where does it go
ingestion inhalation absorption absorptionthrough pregnancy 95% settles in the bones, 1% in blood, 4% in soft tissue
Harmful Effects of Pb in Humans
Neurological effects/ Brain damage
n Anemia – Pb disrupts hemoglobin
production
n Reproductive failure – reduction in fertility
n Kidney damage
– can lead to “ Saturnine Gout” (uric acid accumulates in bone joints)
Historical Aspects of Pb poisoning
n Used by mankind since 4th millenium BC
n Usage increased markedly during Roman Era
n Romans recognized the toxicity of Pb and its fumes –
might have led to the decline of Roman Empire
Historical Aspects of Pb exposure
Bronze Age (3000 to 1200 B.C.)
The dawn of civilization - the alphabet, writing, weapons, cities,
government, public works and civil and religious
administrations
n Iron Age (1200 to 600 B.C.)
The emergence of iron tools and weapons, different agricultural
practices
n Roman Period (70 to 324 A.D.)
Romans constructed roads, amphitheaters and public water
supply
Galena (most important ore of lead)
– a source of silver
- used since ancient times
Roman Pb Artefacts:
- containers used in winery
- also, Pb-acetate (sugar of lead) used as
wine-sweetener
Medieval history of mass Pb poisoning in humans
Pb poisoning became a plague in Europe and
later in America during 15th -18th Centuries.
n In 16th century, Paracelsus described it in
medical literature as “the miner’s disease”.
n In 18th Century, Ramazzini wrote that the potters
who worked with lead became “paralytic,
lethargic with face having the color of lead”