lead Flashcards
greater than 90% burden in adults and 2/3 burden in young children of lead accum occur in the ___
skeleton
clearance time of lead is about ___ for blood and st, ___-___ for bones, and 70% occurs via URINE
1-2mo
years-decades
lead poisoning cause in children, which causes chronic low level exposure and thus decreased intelligence, impaired neurobehav dev, growth stunt, dimin aud acuity
lead based paint
lead has an adverse effect on blood, causing inhib of heme synth and hemolysis, as the NUCLEATED RBC contains ___ ___ of the cytoplasm that suggests a toxic injury to bone marrow
basophilic stippling
lead tox causes peripheral neuropathy, paraesthesia, delirium, and these three others
wrist/food drop
tremor
convulsions
___ ___ is seen with lead tox under the lip
burton’s line
2 early signs of lead poisoning
constipation
metallic taste
two symptoms with advanced lead poisoning
intestinal spasm severe pain (lead colic)
reversible acute tubular dysfx and chronic interstitial fibrosis affect of lead pois on liver
nephrotoxic
lead poisoning causes low sperm prod, increased rate of miscarriage, preterm deliv, and __ __
spontaneous abortion
lead elim half life is 20-30 years, it is dep in bone with greater absorp for kids - this is seen on xray with a visibly dense __ __
metaphyseal band
___ _therapy is used for supportive care, as it binds other agents to facil their excretion
chelation
with severe exposures to lead tox, calcium disodium EDTA or ____ is used and penicillamine for less severe
dimercaprol (BAL)