lead Flashcards

1
Q

greater than 90% burden in adults and 2/3 burden in young children of lead accum occur in the ___

A

skeleton

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2
Q

clearance time of lead is about ___ for blood and st, ___-___ for bones, and 70% occurs via URINE

A

1-2mo

years-decades

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3
Q

lead poisoning cause in children, which causes chronic low level exposure and thus decreased intelligence, impaired neurobehav dev, growth stunt, dimin aud acuity

A

lead based paint

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4
Q

lead has an adverse effect on blood, causing inhib of heme synth and hemolysis, as the NUCLEATED RBC contains ___ ___ of the cytoplasm that suggests a toxic injury to bone marrow

A

basophilic stippling

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5
Q

lead tox causes peripheral neuropathy, paraesthesia, delirium, and these three others

A

wrist/food drop
tremor
convulsions

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6
Q

___ ___ is seen with lead tox under the lip

A

burton’s line

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7
Q

2 early signs of lead poisoning

A

constipation

metallic taste

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8
Q

two symptoms with advanced lead poisoning

A
intestinal spasm
severe pain (lead colic)
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9
Q

reversible acute tubular dysfx and chronic interstitial fibrosis affect of lead pois on liver

A

nephrotoxic

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10
Q

lead poisoning causes low sperm prod, increased rate of miscarriage, preterm deliv, and __ __

A

spontaneous abortion

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11
Q

lead elim half life is 20-30 years, it is dep in bone with greater absorp for kids - this is seen on xray with a visibly dense __ __

A

metaphyseal band

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12
Q

___ _therapy is used for supportive care, as it binds other agents to facil their excretion

A

chelation

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13
Q

with severe exposures to lead tox, calcium disodium EDTA or ____ is used and penicillamine for less severe

A

dimercaprol (BAL)

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