lead

Question 1

greater than 90% burden in adults and 2/3 burden in young children of lead accum occur in the ___

Answer 1

skeleton

Question 2

clearance time of lead is about ___ for blood and st, ___-___ for bones, and 70% occurs via URINE

Answer 2

1-2mo

years-decades

Question 3

lead poisoning cause in children, which causes chronic low level exposure and thus decreased intelligence, impaired neurobehav dev, growth stunt, dimin aud acuity

Answer 3

lead based paint

Question 4

lead has an adverse effect on blood, causing inhib of heme synth and hemolysis, as the NUCLEATED RBC contains ___ ___ of the cytoplasm that suggests a toxic injury to bone marrow

Answer 4

basophilic stippling

Question 5

lead tox causes peripheral neuropathy, paraesthesia, delirium, and these three others

Answer 5

wrist/food drop
tremor
convulsions

Question 6

___ ___ is seen with lead tox under the lip

Answer 6

burton’s line

Question 7

2 early signs of lead poisoning

Answer 7

constipation

metallic taste

Question 8

two symptoms with advanced lead poisoning

Answer 8

intestinal spasm
severe pain (lead colic)

Question 9

reversible acute tubular dysfx and chronic interstitial fibrosis affect of lead pois on liver

Answer 9

nephrotoxic

Question 10

lead poisoning causes low sperm prod, increased rate of miscarriage, preterm deliv, and __ __

Answer 10

spontaneous abortion

Question 11

lead elim half life is 20-30 years, it is dep in bone with greater absorp for kids - this is seen on xray with a visibly dense __ __

Answer 11

metaphyseal band

Question 12

___ _therapy is used for supportive care, as it binds other agents to facil their excretion

Answer 12

chelation

Question 13

with severe exposures to lead tox, calcium disodium EDTA or ____ is used and penicillamine for less severe

Answer 13

dimercaprol (BAL)