arsenic

Question 1

three sources of arsenic - either inorg or organic - in addition to being used in wood preservatives, pesticides

Answer 1

drinking water
rice
seafood

Question 2

arsenic works by inhibiting __ ___ and uncoupling mitochondrial oxidative phosphorylation - damaging epi lining of GI/resp tracts, NS, liver, bone marrow, skin

Answer 2

pyruvate dehydrogenase

Question 3

___ arsenic is more toxic, and is absorbed thru GI tract and lungs, found in drinking water, seafood, folk remedies

Answer 3

INORGANIC

Question 4

acute poisoning by arsenic causes HA, confusion, nausea and vom, but the two most obvious symptoms are:

Answer 4

rice water stools

garlic breath

Question 5

chronic arsenic poisoning causes weight loss, perf nasal sept hair loss, and is mc from:

Answer 5

contaminated well water

Question 6

a pt with chronic arsenic poison will present with this type of complexion bc of anemia and vasodilation

Answer 6

pale and milky / milk and roses

Question 7

arsenic poisoning will present with ____ ____ on the fingernails, aka leukonychia striata, as well as ____ pigmentations

Answer 7

mee’s lines

teardrop

Question 8

chronically inhaled arsenic can cause __ cancer while chronic ingestion can cause __ __ and __ cancer

Answer 8

lung
urinary bladder
skin

Question 9

INORGANIC arsenic poisoning tx is supportive, and chelation therapy with ____

Answer 9

dimercaprol

Question 10

arsenic _____ inhib the opening of voltage sens sodium channels

Answer 10

polyneuropathy

Question 11

____ arsenic is less toxic, with rare poisonings, usually via arsine gas in industrial settings

Answer 11

organic

Question 12

with ORGANIC arsenic poisoning, chelation therapy is inefective, so these two tx are required

Answer 12

renal dialysis

blood transfusion