Last Brown Lecture Flashcards
Tx for hereditary spherocytosis
Splenectomy
Howle-Jelly bodies (left-over DNA) will be present - spherocytes will still be present
EBv results in what abnormal lymphocytes in the peripheral smear?
CD8+ T cells
Howle-Jolle bodies are remnants of?
“Left-over” DNA from hemolytic anemia of spherocytosis
With a presentation of infectious mononucleosis, what is the main DDx?
Hodgkin lymphoma
What are the main two causes of petechiae
- Quantitative platelet dysfunction
- Vasculitis
Cause of palpable purpura
vasculitis
What clotting factor deficiency is indicated by a prolonged PTT and prolonged PT?
Factor V deficiency (common pathway)
What causes the finding of shistocytes in the peripheral smear?
TTP
DIC
HUS
Micro- or macroangiopathic hemolytic anemia
What are the vitamin-K dependent coagulation factors?
How does intravascular hemolytic anemia affect the serum haptoglobin concentration?
Haptoglobin decreases (hemoglobin binds)
Why is free hemoglobin toxic?
Hb is much larger than albumin, disrupts the osmotic balance
In a sickle-cell Pt w/ an autoinfarcted and nonfunctional spleen, what would you expect to see in the peripheral blood smear?
Howell-Jolly bodies
Chronic hemolytic anemias of childhood
Sickle-cell disease
Severe beta-thalassemia
Hereditary spherocytosis
What conditions would you see extramedullary hematopoeisis?
Space occupying lesion in the marrow:
Malignancies in the bone marrow
Myelofibrosis
Granulomas (non-caseating = TB, caseating = sarcoid)
What causes functional asplenia in Pt’s w/ sickle-cell anemia?
Multiple splenic infarcts
