Lambert-Eaton Myasthenic Syndrome (LEMS)

Question 1

LEMS has two cardinal clinical features

Answer 1

muscle weakness in those with small-cell lung cancer.

Question 2

There is decreased release of ______ at the _______.

Answer 2

acetylcholine

neuromuscular junction

Question 3

The key to distinguishing LEMS from myasthenia or the muscle weakness of any paraneoplastic syndrome is that ________________

Answer 3

there is increased strength with increased use.

MG:Worsens with exercise and throughout the day

Question 4

Deep tendon reflexes _____after exercise.

Answer 4

increase

Question 5

Best initial test:

Answer 5

Anti-P/Q-type voltage-gated calcium channel (VGCC) antibody

Question 6

Best initial therapy:

Answer 6

Pyridostigmine

Question 7

Best therapy for acute, severe disease:

Answer 7

IVIG