Huntington Disease

Question 1

what gene and chromosome is affected?

Answer 1

characterized by CAG trinucleotide repeat sequences on chromosome 4.

Question 2

HD is the answer when you see: (cxfx)3

Answer 2

Choreiform movement disorder ( dyskinesia)
Dementia
Behavior changes (irritability, moodiness, antisocial behavior)

Question 3

Onset between the ages of ____with a family history of __

Answer 3

30 and 50 .

HD

Question 4

Movement disorder may be troubling in HD, but it is far worse to progress to ___

Answer 4

no movement at all (rigidity)

Question 5

The movement disorder of HD starts with_________ progressing to_____

Answer 5

“fidgetiness” or restlessness

dystonic posturing, rigidity, and akinesia.

Question 6

Dx

Answer 6

specific genetic test in HD; it is 99% sensitive

Question 7

treatment

Answer 7

No treatment reverses
HD. Treat symptoms
example:
Psychosis: atypical neuroleptics (e.g., clozapine)

Question 8

Dyskinesia is treated with

Answer 8

tetrabenazine.

or deutetrabenazine.

Both are Monoamine‑depleting drugs

Question 9

Psychosis is treated with

Answer 9

haloperidol, quetiapine, or a trial of different antipsychotics

Question 10

______ treat movement disorders such as tardive dyskinesia and Huntington disease. They alter levels of_____

Answer 10

Deutetrabenazine and valbenazine

monoamine (e.g., dopamine, serotonin, norepinephrine).