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Manuf > LAB_Tablets > Flashcards

LAB_Tablets Flashcards

1
Q

Tablets are obtained by compressing uniform volumes of particles or another suitable manufacturing technique like:

A

-Extrusions
-Moulding
-Freeze drying

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2
Q

An applied force causing these
raw materials to go into the dice

A

Extrusion

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3
Q

Tablets are used mainly for ___________ drug delivery and may also be used for local effect.

A

systemic

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4
Q

Compared to liquid formulations, tablets are _________ (more/less) stable chemically, physically and
microbiologically

A

More

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5
Q

Tablets have __________ bioavailability of drugs

A

poor bioavailability of drugs

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6
Q

Tablets are _________ (stable/unstable) in GIT

A

Unstable

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7
Q

the normal way

A

IMMEDIATE -RELEASE

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7
Q

T/F: Tables may cause harm in the gastrointestinal mucosa

A

T

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8
Q

CLASSIFICATION OF TABLETS
ACCORDING TO DRUG RELEASE

A

-IMMEDIATE -RELEASE
-MODIFIED-RELEASE

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9
Q

Drug is released rapidly after administration of the
drug is dissolved in liquid before intake.

A

IMMEDIATE -RELEASE

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10
Q

Example of IMMEDIATE -RELEASE

A

chewable, effervescent, sublingual, buccal

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10
Q

Most common type

A

IMMEDIATE -RELEASE

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11
Q

Liberated from the tablet sometime after
administration and released in normal rapid
after a period has elapsed.

A

Delayed- release

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12
Q

Example of Delayed- release

A

enteric-coated tablet, Voltaren

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13
Q

Delayed release can be combined with _____________ for local treatment

A

prolonged-release

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14
Q

Increased the period of drug absorption after
single administration with 2 or more pulses
release.

A

Pulsatile- release

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15
Q

Pulsatile- release are normally taken in

A

capsule

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16
Q

Drug is released slowly at a nearly constant
rate

A

Prolonged- release

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17
Q

A zero-order type of release is obtained
meaning the rate of elimination is constant
and does not depend on the concentration of
drug in the body.

A

Prolonged- release

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18
Q

Type of tablet that when taken, it’s intended to disintegrate and
dissolve for faster absorption in the gastrointestinal
tract.

A

SWALLOWED TABLETS

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19
Q

most common type of tablet,

A

SWALLOWED TABLETS

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20
Q

“Conventional or plain tablets”

A

SWALLOWED TABLETS

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21
Q

Excipients added in Swallowed Tablets

A

Filler, Diksintegrant, Binder, Glidant, Lubricant, Antiadherent

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22
Q

Are dropped in a glass water and carbon dioxide (
CO ) is liberated before intake for faster disintegration and dissolution.

A
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23
Q

used to prevent formation
of film, normally no binder, includes flavor and
colorants.

A

Water-soluble lubricant

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24
Q

Effervescent Tablets are prepared by ___________ and _______________

A

direct compaction and compaction via
granulation

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25
Q

EXample of Effervescent tablets

A

alkasol sorbifer, Berocca

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26
Q

In effervescent tablets, ___________ reacts
with the bicarbonates/ carbonates they liberate
carbon dioxide. It aids in faster dissolution of the
tablet.

A

Cirtic acid and tartaric acid

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27
Q

Effervescent tablets ___________ the pH temporarily, it
will cause for _____________ and will go
directly to the ___________ and be absorbed there.

A

increases; rapid gastric emptying; small intestine

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28
Q

Chewed to facilitate quick disintegration of the
tablets and absorption in gastrointestinal tract or
intestine

A

CHEWABLE TABLETS

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29
Q

T/F: Chewable tablets can be taken when water is not available

A

T

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30
Q

Chewable tablets normally doesn’t have __________

A

disintegrant

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31
Q

used as fillers in chewable tablets, has
flavoring agent and colorant

A

Mannitol and sorbitol

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32
Q

They are attractive form of tablet and they are given
to patients that have troubles in swallowing such as
elderly patients and children.

A

CHEWABLE TABLETS

33
Q

under the tongue

A

Sublingual-

34
Q

example of. tablet that is administered sublingually

A

Clonidine

35
Q

side of the cheek or between upper lip and
gum the lips

A

Buccal

36
Q

Buccal tablets are absorb directly by the veins which goes straight to the ____________ between the gum and front lips or cheeks. It avoids
first-pass effect.

A

superior vena cava

37
Q

used to to adhere (in the cheeks/ under the tongue) in place forming a gel

A

High molecular weight hydrophilic polymers and/ or
gums,

38
Q

__________ coated tablets are used for palatability, aesthetic appeal

A

Sugar coated

39
Q

Sugar coated may
take ______ - _______ coats of concentrated syrup
solution

A

Sugar coated may
take ______ - _______ coats of concentrated syrup
solution

39
Q

Pass through the stomach unaltered - release
the effect within the intestinal tract

A

Enteric coated

40
Q

The coating is designed to rupture and expose
the core tablet at the desired location in the
gastrointestinal tract.

A

Film coated

40
Q

Protect the drug from destruction by gastric
fluid or to aboid gastric irritation/ bypass of the
gastrointestinal tract enhances drug
absroption

A

Enteric coated

41
Q

It will not disintegrate right away because
there is a desired location wherein, it will be
absorbed or disintegrated for absorption.

A

Film coated

42
Q

is a capsule-shaped comparessed
tablet, coated with gelatin to facilitate
swallowing

A

Gelatin coated tablets

42
Q

used to protect the contents from light,
atmospheric oxygen, contamination and any
microbial growth.

A

Gelatin

43
Q

it is the process of adding lubricant to the dry
granules while passing through a sieve
#60-100)

A

Bolting

43
Q

T/F: Gelatin can also mask the taste of unpalatable
tablet.

A

T

44
Q

Example of Gelatin capsule

A

extra Strength Tylenol PM Gelcaps

44
Q

Upper part of mold is for

A

die

45
Q

Type of granulation that uses roller compactor

A

Dry granulation

46
Q

Sieve no. used in dry granulation

A

12

47
Q

Sieve no. used in wet granulation

A

6 or 8; then 12 after dring, then #60-100 while bolting

48
Q

Bolting is done during _______ granulation

A

wet

49
Q

MOLDED TABLETS

A

“Tablet triturates”

50
Q

Lower part of mold is for

A

punches

51
Q

Molds are wetted with __________ mixture of ______ and ________

A

50%; water and alcohol

52
Q

FILLER a.k.a ________

A

DILUENT

53
Q

Tablets normally weighs at least _______ mg

A

50

54
Q

Ideal filler:

A
  • Chemically intert
  • Non hygroscopic
  • Biocompatible
  • Possess good biopharmaceutical and
    technical properties
  • Palatable
  • Reasonable cost
55
Q

Examples of filler

A

Lactose, sucrose, glucose, mannitol, sorbitol, dicalcium
phosphate dihydrate, calcium carbonate and
cellulose

56
Q

Promote breakup of the tablets after
administration to smaller particles for ready drug
availability

A

DISINTERGANT

57
Q

Example of disintegrant

A

Starch, cellulose, cross-linked
polyvinylpyrrolidone (PVP) (very common),
sodium starch glycolate (SGG), sodium
carboxymethylcellulose (CMC) and
(Croscarmellose sodium)

58
Q

“The glue”

A

BINDER (ADHESIVE)

59
Q

Added to a fillers to ensure granules and tablets
have required mechanical strength

A

BINDER (ADHESIVE)

60
Q

Binders can be added as ____________ + other ingredients before wetting

A

Dry powder

61
Q

Binders can be added as Solution (solution binder) glucose ________,
starch paste ___________

A

25-50%; 10-20%

62
Q

Dry binders

A

microcrystalline cellulose and
cross-linked polyvinylpyrrolidone (PVP)

63
Q

Traditional binders

A

starch, sucrose, gelatin

64
Q

Modern binders

A

polymers like
polyvinylpyrrolidone (PVP) and hydroxypropyl
cellulose (HPC) cellulose derivatives - wet
granulation

65
Q

Improve flowability of the powder

A
66
Q

Glidants are added to granules __________ tableting to ensure
flowability

A

before

67
Q

Traditional glidant

A

talc (1-2% by weight)

68
Q

Modern glidant

A

colloidal silica (0.2% by weight)

69
Q

can be glidant and lubricant

A

Magnesium stearate

70
Q

Ensure that tablet formation and ejection can occur
with low friction between the solid and the die wall

A

LUBRICANT

71
Q

between moving surfaces
of the solids.

A

Fluid lubrication

72
Q

film lubricant.

A

Boundary lubrication

73
Q

EXamples of Boundary lubrication

A

Stearic acid or stearic acid salts

74
Q

Examples of lubricants

A

magnesiums sterate (1%), Talc 5%,
stearic acid, sodium stearyl fumarate

75
Q

Antiadherents reduce adhesion between the powder and the
punch faces and thus prevent particles _________ to the punches.

A

sticking/
picking

76
Q

examples of antiadherent

A

● Magnesium stearate - anti adherent
● Talc
● Starch
● Cellulose

77
Q
A

Manuf (12 decks)

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