Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Manuf > Act 9 > Flashcards

Act 9 Flashcards

1
Q

Prepared agglomerates of smaller particle size

A

Granules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Granules are _________ shaped and behaved as a single particle

A

Irregularly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

T/F: Granules may be prepared spherical

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

In the preparation of granules, we make use of sieve no.

A

sieve #4-12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

________ are preparation consisting of solvent, dry
aggregates of powder quantity sufficienty resistant
that can withstand handling.

A

Granules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Granules are intended for

A

oral administration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

T/F: Granules are swallowed, chewed, dissolved or dispered in water or
another suitable solvent before administered to the patient.

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

T/F: Granules contain one or more active substances
with or without excipients and if possible you can
add suitable colorants and flavorant substances.

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Disadvantages of Granules

A
  • Particle size differences
  • ingredients may segregate either in the hopper’s of the packaging machine or storage in the final bulk container.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Granules are mainly used for ______ (low/high) toxicity, ________ (low/high)
dose drugs

A

low; high

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

used as a bulk-forming laxative and has a dose of 1-4g daily.

A

methylcellulose granules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

T/F: single dose granules are enclosed in an individual container.

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Preparations containing volatile ingredients must be stored in an

A

airtight container

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Methylcellulose granules are stored in a

A

wide mouth airtight container

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

uncoated granules containing acid substances
and carbonates or Hydrogen carbonates
which react rapidly in the presence of water
and release carbon dioxide.

A

Effervescent granules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Intended to be
dissolved or dispersed in water prior to
administration

A

Effervescent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Consists of granules coated with one or more
layers of mixtures of various excipients.

A

Coated granules

18
Q

Substances used as coatings, generally
Polymers, are usually applied as solution or
suspension in conditions in which evaporation
of the vehicle occurs leaving a film ot coating

A

Coated granules

19
Q

It is also referred to as enteric coated.

A

Gastro-resistant

20
Q

Gastro-resistant granules
are ___________granules that are intended
to resist gastric fluid release of the active
substances in the intestinal fluid.

A

delayed release

21
Q

Coated or uncoated granules that contain
special excipients or which are prepared by
special procedures both designed to modify
the rate, place, time at which the active
substances are released.

A

Modified release

22
Q

Pharmaceutical process which attempts to
convert powdered materials into aggregates

A

Granulation

23
Q

TYPES OF GRANULATION

A

Dry granulation
Wet granulation
Fluid bed granulation

24
Q

Allows granulation with or without moisture

A

Granulating machine/Granulator

25
Q

Employed in large scale manufacturing

A

Granulating machine/Granulator

26
Q

granules are formed by compacting
large masses of the powder mixture and
subsequently crushing it into pieces.

A

Dry granulation

27
Q

requires the drug or the diluent to
have cohesive properties to form large
masses.

A

Dry granulation

28
Q

Involves wetting powder mixture, sieving and
drying in preparation of granules

A

Wet granulation

29
Q

A liquid binder or an adhesive is first
added to the powder mixture. The moist
mass is then passed through a screen
of the desired mesh size and the
resulting granules are dried. The dried
granules can be passed through the
second screen of a smaller mesh to
reduce the size of the granules, even
powder.

A

Wet Granulation method

30
Q

results in granules that are too hard for
proper tableting.

A

Overwetting

31
Q

results to soft tablets that tends to
crumble

A

Underwetting

32
Q

3rd method of granulation

A

Fluid bed granulation

33
Q

T/F: Since microparticles are considered as
granules, approaches of making
microparticles such as fluid bed drying
technology can be used for granulation.

A

T

34
Q

A granulating solution is sprayed on to the
suspended particles that are then dried
rapidly in the suspending air.

A

Fluid bed granulation

35
Q

Penicillin G is also known as

A

Benzyl Penicillin

36
Q

Penicillin V is also known as

A

Phenoxymethyl

37
Q

A modified penicillin having C6H5OCH2 as
radical

A

Penicillin V

38
Q

Relatively stable in the presence of gastric
acidity, soluble in duodenal fluids and orally
effective without buffer

A

Penicillin V

39
Q

Pharmacologic category of PHENOXYMETHYL PENICILLIN
POTASSIUM GRANULES FOR ORAL SOLUTION

A

Antibacterial
Anti-infective derived from natural source

40
Q

provides faster and higher blood level than
phenoxymethyl penicillin

A

Oral Pen V. Potassium

41
Q

CGMP requirement of Antibacterial prep

A

Must be manufactured in a separate area from
non-penicillin

Manuf (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions