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Manuf > Act 8 > Flashcards

Act 8 Flashcards

1
Q

A mixture of finely divided drugs and/or chemicals in
a dry form

A

POWDER

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2
Q

2 forms of powders

A

○ Amorphous
○ Crystalline

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3
Q

Powders according to size

A

V. coarse
Coarse
M. Coarse
Fine
V. Fine

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4
Q

All particles pass through a
No. 8 sieve and not more
than 20% pass through a
No. 60 sieve

A

Very coarse

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5
Q

All particles pass through a
No. 20 sieve and not more
than 40% pass through a
No. 60 sieve

A

Coarse

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6
Q

All particles pass through a
No. 40 sieve and not more
than 40% pass through a
No. 80 sieve

A

Moderately coarse

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7
Q

All particles pass through a
No. 60 sieve and not more
than 40% pass through a
No. 100 sieve

A

Fine

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8
Q

All particles pass through a
No. 80 sieve. There is no
limit to greater fineness

A

Very fine

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9
Q

Powders when to be used internally is administered through the

A

nose snuffs or Blown into a body cavity

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10
Q

powders
applied as extreme finely
divided particles into a body
cavity such as, nose, ears,
throat, vagina with the help of a
device known as insufflators.

A

Insufflations

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11
Q

Locally applied
non-toxic preparation and no systemic
effect. They are applied as lubricant,
protective, absorbent, antiseptic,
antipruritic, astringent, anti-perspirant

A

Dusting powders

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12
Q

2 types of Dusting powders

A

Medical, Surgical

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13
Q

Used to clean and
polish the teeth

A

Dentifrices

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14
Q

Initially
dissolved in water to be used as
an antiseptic or cleansing agent
for a body cavity

A

Douche powder

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15
Q

Douche powder and Dentifrices are powders used ____ (internally/externally)

A

externally

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16
Q

Also known as undivided powders

A

Bulk powders

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17
Q

Dusting powders, Effervescent,
Antacids, Laxatives, Dietary nutrient and
supplements,

A

Bulk powders

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18
Q

simple mixture of the
prescribed medication without additional ingredients.
Dispensed usually involved bulk quantities

A

Oral undivided powders

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19
Q

If intended for external dusting powders, Oral undivided powders can be placed in a

A

perforator or sifter

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20
Q

If applied on skin, Oral undivided powders can be placed in a

A

aerosol container

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21
Q

for easy removal
of a spoonful of powder, Oral undivided powders can be placed in a

A

a wide mouth glass

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22
Q

Pockets, Mache, Capsules,

A

Divided powder

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23
Q

contain one or more
active ingredient/s together with inner diluents
to produce a minimum quantity of 120 mg.

A

Divided powder

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24
Q

T/F: Divided powder can be dispensed in a single-dose quantity,
usually folded in paper

A

T

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25
Q

T/F: Divided powder can be dispensed in metal foil or small sealed
or reusable plastic bag container

A

T

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26
Q

REQUIREMENTS IN MANUFACTURING OF POWDER

A

HOMOGENEOUS BLENDING
REDUCTION

27
Q

The purpose of this step is to increase the exposure
of poorly soluble drug by increasing surface active
area, thereby, improving dissolution rate

A

REDUCTION

28
Q

BLENDING TECHNIQUES

A

SPATULATION
TRITURATION
GEOMETRIC DILUTION
SIFTING

29
Q

A method of blending a small amount of powder by
movement of pharmaceutical spatula on a sheet of
paper or ointment tile, in very little compression or
compacting of the powder results from spatulation.

A

spatulation

30
Q

It is especially said for mixing solid substances that
liquefy or form eutectic mixture.

A

spatulation

31
Q
  • mixtures that melt at
    lower temperature than any other
    ingredients whether close and prolong
    contact with one another.
A

Eutectic mixture

32
Q

T/F Eutectic mixture is not suitable
for large quantities of powder and not
recommended for powders containing
potent substances.

A

T

33
Q

Provides intimate building of powder using
porcelain, wedgwood, glass mortar. Not
recommended for eutectic mixtures

A

TRITURATION

34
Q

T/F In trituration, porcelain or ceramic mortar with erupt
inner surface is prepared than a glass
mortar with a smooth working surface

A

T

35
Q

T/F: A glass mortar is preferred for chemical
substances that stains porcelain or
ceramic surface as well as simple
admixture of substance without a
special need for comminution.

A

T

36
Q

Used for mixing potent substances with a large
amount of diluent. Potent drug is placed on an
approximately equal volume or amount of diluent in
a mortar and mixed by trituration.

A

GEOMETRIC DILUTION

37
Q

Recommended on instances in which the potent
and non-potent substances are of the same color or
visible sign of thorough mixing is lacking.

A

GEOMETRIC DILUTION

38
Q

The simplest and most commonly used method of
mixing powder or particle size determination.

A

SIFTING

39
Q

This involves tumbling a powder in a rotating
chamber or mixing powder using a large enclosed
container rotated by a motorized process.

A

TUMBLING

40
Q

Study of Particle Size. It is the science of small
particles. It is important to study small particles
since most drug dosage forms are solid.

A

Micromeretrics

41
Q

T/F: Solids are not static systems.

A

T

42
Q

The physical
states of solids can be altered by ______ and particle characteristics in
altered therapeutic effectiveness.

A

physical
manipulation

43
Q

Process of reducing particle size with a finer
state of subdivision.

A

Comminution

44
Q

determines the volume distribution of
particles suspended in an electrolyte
containing solution

A

Coulter counter

45
Q

TECHNIQUES IN PARTICLE SIZE DETERMINATION

A

Sieving (40 - 9500 micrometers)
Coulter counter

46
Q

Drug micronization can increase dissolution
rate and its bioavailability

A

Suspendability

47
Q

suspendability of particles intended to remain
undissolved but uniformly dispersed in a
liquid vehicle.

A

Suspendability

48
Q

Ensures dose-to-dose content uniformity

A

Uniform distribution

49
Q

drugs intended to be inhaled or positioned in
the respiratory tract.

A

Penetrability

50
Q

observed in dermal ointment, creams, and
ophthalmic preparations

A

Lack grittiness

51
Q

COMMINUTION TECHNIQUE

A

Milling
Trituration
Levigation
Pulverization with intervention

52
Q

employed in a large-scale production. A
mechanical process of reducing particle size
before mixing with other components, product
processing, or incorporation into a final
product.

A

Milling

53
Q

Substance is reduced into smaller particles
by rubbing it on a mortar and pestle.

A

Trituration

54
Q

The particle size of a substance is reduced
by adding a suitable non-solvent levigating
agent to form a paste. The paste is then
rubbed using a mortar and pestle or using an
ointment slab and spatula.

A

Levigation

55
Q

Substances are reduced and subdivided with
an additional material- which is solvent, that
can be removed easily after pulverization is
complete.This

A

Pulverization with intervention

56
Q

_________ technique is applied to
substances which are gummy that intend to agglomerate and resist grinding.

A

Pulverization with intervention

57
Q

Administration of fluid and electrolyte by
mouth to prevent/treat dehydration due to
acute diarrheal disease

A

Oral Rehydration therapy

58
Q

Normal physiologic body response
to aid itself of a noxious toxic substance.
Characterized by an increased frequency of
loose watery stool. Can cause dehydration

A

Diarrhea

59
Q

Effective in the treatment of patients with mild
volume depletion of 5-10% of Body Weight

A

Oral Rehydration Salt

60
Q

Advantages of ORS

A

OTC, Inexpensive, Diminishes
incidence of complications associated with
parenterally administered electrolyte solution

61
Q

is a good source of sodium, potassium, and
chloride

A

Potassium chloride

62
Q

helps correct the subsequent metabolic acidosis
which is cost by diarrhea and dehydration

A

Sodium chloride

63
Q

glucouse transport is coupled with sodium
absorption

A

Anhydrous glucose

Manuf (12 decks)

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