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Manuf > Act 7 > Flashcards

Act 7 Flashcards

1
Q

a disperse system in which internal phase is
dispersed uniformly as dinely divided insoluble
particles throughout the external phase.

A

Suspension

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2
Q

Suspension is a a disperse system in which ___________ is
dispersed uniformly as dinely divided insoluble
particles throughout the ________

A

internal phase; external phase.

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3
Q

consist of insoluble solid particles
having the range of 0.5 to 5 microns
which is maintained uniformly
throughout the suspending vehicle.

A

Internal Phase

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4
Q

generally aqueous and in some
instances it may be an organic liquid or
oily liquid for non-oral use

A

External Phase

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5
Q

Suspensions Based on General Classes

A

○ Oral suspension
○ Externally Applied suspension
○ Parenteral Suspension

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6
Q

Suspensions Based on Proportion of Solid Particles

A

○ Diluted suspension
○ Concentrated suspension

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7
Q

Suspensions Based on Electro Kinetic Nature of Solid
Particles

A

○ Flocculated suspension
○ Deflocculated suspension

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8
Q

Suspensions Based on Size of Solid Particles

A

○ Colloidal suspension
○ Coarse suspension

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9
Q

REASONS FOR THE FORMULATION OF A SUSPENSION

A

● Sustaining effect
● Stability
● Taste
● basic solubility

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10
Q

COMPONENTS OF A SUSPENSION

A

API
Wetting agents
Flocculating agents
Viscosity Agents
Buffer
Preservative, colorant, flavorant
Water, glycerin, sorbitol

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11
Q

The API in Suspensions is (soluble/insoluble) in vehicle

A

insoluble

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12
Q

Also known as surfactants

A

Wetting agents

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13
Q

added to disperse solid particles in
the external phase

A

Wetting agents

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14
Q

Sodium lauryl sulfate, benzalkonium
chloride

A

Wetting agents

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15
Q

Agents which are capable of preventing the
caking of suspended particles

A

Flocculating agents

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16
Q

calcium chloride, aluminum chloride

A

Flocculating agents

17
Q

Also known as suspending agents or
thickeners

A

Viscosity agents

18
Q

Added to increase viscosity of the
suspension

A

Viscosity agents

19
Q

methylcellulose, bentonite, tragacanth

A

Viscosity agents

20
Q

Added to stabilize the suspension in the
desired pH range

A

Buffer

21
Q

Aluminum Magnesium Hydroxide Suspension is an

A

ANTACID.

22
Q

Antacids are substances which reduce the gastric
acidity resulting in an (decrease/increase) in the pH of
the stomach and in the duodenum.

A

increase

23
Q

also used to neutralize excess gastric
hydrochloric acid associated with gastritis
and peptic ulcer.

A

Antacids

24
Q

Most antacids raise the gastric pH to ____.

A

4-5

25
Q

widely used for:
○Uncomfortable feeling from overeating
○ Heartburn
○ Dyspepsia (indigestion)
○ Duodenal ulcer
○ Other non-specific GI symptoms

A

Antacids

26
Q

Considered as an ideal antacid

A

ALUMINUM HYDROXIDE

27
Q

ALUMINUM HYDROXIDE is soluble in

A

acidic medium

28
Q

Color of Al(OH)3

A

White

29
Q

T/F: Al(OH)3 is a viscous suspension

A

T

30
Q

pH of Al(OH)3

A

pH 5.5 - 8.0

31
Q

Disadvantages of Al(OH)3

A
  • may interfere with the 3
    absorption of other drugs by binding
    with them
  • Can cause constipation due to the
    production of Aluminum Chloride
32
Q

White, fine odorless, amorphous powder

A

MAGNESIUM HYDROXIDE

33
Q

MAGNESIUM HYDROXIDE is Insoluble in water and alcohol but soluble in ________

A

dilute acids

34
Q

Laxatives in high doses

A

MAGNESIUM HYDROXIDE

35
Q

■ Fast onset of action
■ No systemic alkalosis
■ High Acid neutralizing capacity

A

MAGNESIUM HYDROXIDE

36
Q

■ Short duration of action
■ laxative/ diarrhea
■ Hypermagnesemia
■ Contraindicated to patients with kidney
disease

A

MAGNESIUM HYDROXIDE

37
Q

wetting agent in prepping for Al(OH)3

A

Sorbitol Solution

38
Q

suspending agent in prepping for Al(OH)3

A

Carboxymethyl cellulose

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