Act 7 Flashcards
a disperse system in which internal phase is
dispersed uniformly as dinely divided insoluble
particles throughout the external phase.
Suspension
Suspension is a a disperse system in which ___________ is
dispersed uniformly as dinely divided insoluble
particles throughout the ________
internal phase; external phase.
consist of insoluble solid particles
having the range of 0.5 to 5 microns
which is maintained uniformly
throughout the suspending vehicle.
Internal Phase
generally aqueous and in some
instances it may be an organic liquid or
oily liquid for non-oral use
External Phase
Suspensions Based on General Classes
○ Oral suspension
○ Externally Applied suspension
○ Parenteral Suspension
Suspensions Based on Proportion of Solid Particles
○ Diluted suspension
○ Concentrated suspension
Suspensions Based on Electro Kinetic Nature of Solid
Particles
○ Flocculated suspension
○ Deflocculated suspension
Suspensions Based on Size of Solid Particles
○ Colloidal suspension
○ Coarse suspension
REASONS FOR THE FORMULATION OF A SUSPENSION
● Sustaining effect
● Stability
● Taste
● basic solubility
COMPONENTS OF A SUSPENSION
API
Wetting agents
Flocculating agents
Viscosity Agents
Buffer
Preservative, colorant, flavorant
Water, glycerin, sorbitol
The API in Suspensions is (soluble/insoluble) in vehicle
insoluble
Also known as surfactants
Wetting agents
added to disperse solid particles in
the external phase
Wetting agents
Sodium lauryl sulfate, benzalkonium
chloride
Wetting agents
Agents which are capable of preventing the
caking of suspended particles
Flocculating agents
calcium chloride, aluminum chloride
Flocculating agents
Also known as suspending agents or
thickeners
Viscosity agents
Added to increase viscosity of the
suspension
Viscosity agents
methylcellulose, bentonite, tragacanth
Viscosity agents
Added to stabilize the suspension in the
desired pH range
Buffer
Aluminum Magnesium Hydroxide Suspension is an
ANTACID.
Antacids are substances which reduce the gastric
acidity resulting in an (decrease/increase) in the pH of
the stomach and in the duodenum.
increase
also used to neutralize excess gastric
hydrochloric acid associated with gastritis
and peptic ulcer.
Antacids
Most antacids raise the gastric pH to ____.
4-5
widely used for:
○Uncomfortable feeling from overeating
○ Heartburn
○ Dyspepsia (indigestion)
○ Duodenal ulcer
○ Other non-specific GI symptoms
Antacids
Considered as an ideal antacid
ALUMINUM HYDROXIDE
ALUMINUM HYDROXIDE is soluble in
acidic medium
Color of Al(OH)3
White
T/F: Al(OH)3 is a viscous suspension
T
pH of Al(OH)3
pH 5.5 - 8.0
Disadvantages of Al(OH)3
- may interfere with the 3
absorption of other drugs by binding
with them - Can cause constipation due to the
production of Aluminum Chloride
White, fine odorless, amorphous powder
MAGNESIUM HYDROXIDE
MAGNESIUM HYDROXIDE is Insoluble in water and alcohol but soluble in ________
dilute acids
Laxatives in high doses
MAGNESIUM HYDROXIDE
■ Fast onset of action
■ No systemic alkalosis
■ High Acid neutralizing capacity
MAGNESIUM HYDROXIDE
■ Short duration of action
■ laxative/ diarrhea
■ Hypermagnesemia
■ Contraindicated to patients with kidney
disease
MAGNESIUM HYDROXIDE
wetting agent in prepping for Al(OH)3
Sorbitol Solution
suspending agent in prepping for Al(OH)3
Carboxymethyl cellulose
