LAB - 4 - Routes... Flashcards
2 Types of Systemic Routes:
Enteral
Parenteral
Enteral Routes:
Oral
Sublingual
Rectal
Parenteral Routes:
Inhalation
Injections
Transdermal
Administration of a drug by mouth.
Oral Route
This route is easily self-administered, limits the number of systemic infections, and is exposed to the harsh gastrointestinal environment, which may limit absorption.
Oral Route
Most drugs absorbed from the GI tract enter the portal circulation and encounter the liver before they are distributed into general circulation, known as ___
“First Pass Metabolism.”
Advantages of oral route:
Safe
Convenient
Painless
Economical
Self-administered
Disadvantages of oral route:
Slow onset
First pass effect
Drugs destroyed by digestive juices
Cannot be given to unconscious or uncooperative patients
A method where a tablet or pellet containing the drug is placed under the tongue or crushed in the mouth and spread over the buccal mucosa, allowing for rapid absorption into the bloodstream, bypassing the liver.
Sublingual/Buccal Route
Advantages of Sublingual/Buccal Route:
Quick onset of action
Bypasses first pass effect
Can be spat out if side effects occur
Disadvantages of Sublingual/Buccal Route:
Distasteful drugs cannot be given
Drugs with high molecular weight are not well absorbed
Swallowing may deactivate the drug
Drugs are administered rectally as a suppository, mixed with a waxy substance that dissolves or liquefies after insertion into the rectum.
Rectal Route
Advantages of Rectal Route:
Useful in patients with nausea and vomiting
Bypasses first pass effect
Useful if the drug is a gastric irritant
Disadvantages of Rectal Route:
Chances of rectal inflammation
Absorption is unreliable
Inconvenient and embarrassing for the patient
Parenteral Routes
Intravenous (IV)
Direct administration of drugs into the bloodstream.
Advantages of Parenteral Routes:
Quick onset
Bypasses first pass effect
Useful in unconscious patients
Allows large volume fluids
Gastric irritant drugs may be given
Amount of drug is controlled
Also known as a spinal tap, is a test used to diagnose certain health conditions. It’s performed in your lower back, in the lumbar region. During this, a needle is inserted into the space between two lumbar bones, called vertebrae. Then a sample of cerebrospinal fluid is removed.
Lumbar puncture
Intraarterial Administration is for:
Vasodilator drugs in treatment of vasospasm
Thrombolytic drugs in treatment of embolism