Lab 3.7 Cases Flashcards
Haemorrhagic necrosis in the intestinal, respiratory tracts and visceral organs,
associated with neurological and GI clinical signs could mean WHICH DISEASE?
newcastle disease
specifics surrounding newcastle virus (6)
-Family Paramyxoviridae/ Genus Avulavirus
-9 serotypes (Avian Paramyxovirus)
-APMV-1 to APMV-9
-Newcastle disease is APMV-1
-ssRNA, enveloped, pleomorphic
-All avian species have demonstrated some level of susceptibility (chicken and cormorants!)
How does the virulence of Newcastle disease virus influence the
pathogenesis of the disease? (4)
1) Asymptomatic
2) Lentogenic: subclinical to mild respiratory
3) Mesogenic: respiratory or neurological
4) Velogenic: most pathogenic
4.1 Velogenic neurotropic: respiratory and neurological
4.2 Velogenic viscerotropic: hemorrhagic intestinal
what pathotypes are considered virulent newcastles disease
3) Mesogenic: respiratory or neurological
4) Velogenic: most pathogenic
4.1 Velogenic neurotropic: respiratory and neurological
4.2 Velogenic viscerotropic: hemorrhagic intestinal
clinical signs of purulent newcastle disease (7)
- Drop in egg production
- Numerous deaths within 24 to 48 hours
- Deaths continue for 7 to 10 days
- Respiratory signs
- Surviving birds may have neurological damage
- Edema of head, especially around eyes
- Greenish, dark watery diarrhea
What methods can we use to determine the virulence/pathotype of ND?
1) Sequencing of the fusion protein
2) Intracerebral index pathogenicity (1-day old chicks)
post mortem findings of virulent ND
- Edema of head and neck
- Edema, hemorrhage, necrosis or
ulceration of lymphoid tissues - Hemorrhagic lesions
– Tracheal mucosa
– Proventriculus
– Intestinal mucosa
Modes of introduction of NDV between flocks
-Moving live infected birds (including vaccinated birds), and infected poultry products
-Moving people and equipment
-Airborne spread
-Contaminated poultry feed
-Contaminated water
-Vaccines
what is the most susceptible domestic poultry species to NDV?
poultry
What will you recommend to a farm to eradicate NDV?
- Depopulation of all remaining animals
- Cleaning and disinfection
- APMV-1 may survive in contaminated, uncleaned poultry houses for up to 16 days after depopulation
- Strict quarantine of new animals
is NDV zoonotic
yes
details of canine distemper virus
-Enveloped virus- what does it mean
for control/prevention of the disease?
-Common clinical signs include
respiratory, GI and neurological.
-Disease of the immune system and
infects mostly leukocytes
(immunosuppression)
Long-term consequences of Canine Distemper
- Can occasionally see foot pad hyperplasia and enamel hypoplasia in dogs that were acutely infected and managed to survive the infection
- Can also see permanent neurological damage
what species are at risk of CDV?
One of the most important viral
diseases in ferrets
transmission of CDV
Transmitted through droplet infection, direct contact with another infected animal
