L9_Antibody-mediated immunity

Question 1

What are the four functions of antibody in humoral immunity?

Answer 1

1. Neutralization
2. Opsonization
3. Complement fixation (Complement-dependent cytotoxicity or CDC)
4. Antibody- dependent cytotoxicity (ADCC)

Question 2

Which class of antibody has the function of neutralization, opsonization and ADCC?

Answer 2

IgG

Question 3

Which class of antibody are mostly found in secretions and mucosal surface?

Answer 3

IgA

Question 4

Which class of antibody play an important role in allergy and asthma?

Answer 4

IgE

Question 5

Which class of antibody is effective in binding and neutralizing antigens and complement fixation?

Answer 5

IgM

Question 6

Which Ig class has effect on NK cells?

Answer 6

IgG

Question 7

Can a single antibody activate an Fc receptor?

Answer 7

No

Question 8

Give an example of an Fc receptor containing ITIM？

Answer 8

Fc-gamma-R two (CD32)

Question 9

What is the function of CD32?

Answer 9

When bound by IgG-antigen complex, sends negative signals to dendritic cell;
Thus, preventing dendritic cell from being activated by low levels of antibody-antigen complex

Question 10

Which enzyme is related to class switch recombination?

Answer 10

Activation-induced cytidine deaminase (AID)

Question 11

ITIM recruits phosphatase or kinase?

Answer 11

Kinase

Question 12

Extracellular pathogen biased the B cell to secrete which class of antibody?

Answer 12

IgM

Question 13

Intracellular pathogen biased the B cell to secrete which two classes of antibody?

Answer 13

IgG and IgA