L6_Innate immunity

Question 1

Which TLR is related to viral dsRNA?

Answer 1

TLR 3

Question 2

Which TLR is related to viral ssRNA?

Answer 2

TLR 7/8

Question 3

Which TLR is related to bacterial DNA?

Answer 3

TLR 9

Question 4

Which TLR is related to LPS (lipopolysaccharide)?

Answer 4

TLR 4

Question 5

What are the 3 pathways of TLR signaling?

Answer 5

1. MyD88/NFkB
2. MAPK (Mitogen activated protein kinase)/ AP-1
3. IRF(Interferon regulatory factor)7 and IRF3/ IFNα and IFNβ

Question 6

What are the downstream events for IFNα and IFNβ?

Answer 6

IFNAR 1&2/ JAK-STAT/ Antiviral proteins (Protein Kinase R; 2’-5’ oligoA synthetase)