L10_ Cell mediated immunity

Question 1

What are the recognition molecules for cytotoxic T cells?

Answer 1

TCR/ MHC class one with peptides

Question 2

What are the 2 killing mechanisms for Tc cells?

Answer 2

1. Granzyme & perforin
2. Fas-FasL interaction

Question 3

What are the two activating receptors for NK cells?

Answer 3

1. NKG2D (Natural Killer Group 2 Member D)
2. NCR(Natural Cytotoxicity Receptors)

Question 4

NK cells can also recognize of lack of inhibitory receptor, give 2 examples of this.

Answer 4

1. CD 94- NKG2A :: HLA-E
2. KIR2DL(Killer Immunoglobulin-like Receptor (KIR)) :: HLC-C

Question 5

What are the 3 killing mechanisms for NK cells?

Answer 5

1. Fas- FasL interaction
2. Granzyme & perforin
3. ADCC

Question 6

What is the killing mechanism for NKT cells?

Answer 6

Fas- FasL interaction

Question 7

What is the recognition process of NKT cells?

Answer 7

semi-invariant TCR recognizing CD1d presenting lipids