L5_Receptors and signaling: Cytokines and chemokines Flashcards
What are the cytokines that are involved in innate immune response?
IL-1 and TNF α
What is the cytokine that induce Th1 differentiation?
IL-12
What is the cytokine that induce Th2 differentiation?
IL-4
What is the cytokine that induce Th17 differentiation?
IL-23
What is the most important Th1 cytokines?
IFN-γ
What are the 2 most important Th2 cytokines?
IL-4 and IL-5
What is the cytokine that can promote both Th1 and Th2?
IL-2
What are 2 major anti-virus cytokines?
IFN-α and IFN-β
Give an example of chemo-attractant.
IL-8
What are the 2 pathways that IL-1 family can trigger?
- MyD88/ IRAK (Interleukin-1 Receptor Associated Kinase)/ NFkB
- AP-1pathway
What is the pathway that Class one and Class two cytokine family can trigger?
JAK-STAT pathway
What is the pathway that TNF family can trigger?
FasL-Fas/ FADD/ Caspase
What is the pathway that IL-17 family can trigger?
Receptor trimmer/ inflammation and autoimmune
What is the pathway that Chemokines can trigger?
G-Protein Coupled Receptor (GPCR)/ G-protein signaling/ Rho/ Cytoskeletal rearrangement
List the Th1 cytokines
- IFN- gamma
- IL-2
- TNF-alpha
List the Th2 cytokines
- IL-4
- IL-5
What are the 6 families of cytokines based on structures?
- Interlukins
- Hematopoietin (Class one) family cytokines
- Interferons (Class two) family cytokines
- Tumor necrosis factor (TNF) family
- IL-17 family
- Chemokines
What is the function of IL-1?
Proinflammatory
What are the principar producers of cytokines?
Th cells, dendritic cells and macrophages
What is the unique structrual feature of chemokines?
Disulfide brideges between cysteines in chemokine structures
Compared to G proteins such as Ras, what is different in chemokines receptors?
Chemokines receptors are larger and polymeric, while Ras is small and monomeric
