L3_Structure of antibodies

Question 1

Hinge region is rich in proline residues, this gives rise to what property of the antibody?

Answer 1

Flexibility of the two antigen-binding arms, thus facilitates efficient antigen binding

Question 2

What is the chemical feature of the hinge region?

Answer 2

It is rich in proline and contains cysteines

Question 3

Hinge region contains cysteines, what does cysteines participate in?

Answer 3

They participate in heavy chain dimerization