L9- vascular resistance Flashcards

1
Q

what are elastic arteries

A

larger vessels that has SM and elastic fibres in them

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2
Q

what is the driving pressure in the CVS

A

arterial blood pressure which is the ejection of blood from the ventricle leading to a pulsatile pressure in the aorta and large arteries

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3
Q

functions of elastic arteries (EA)s

A
  • dampening pulsatile pressure for continuous flow into the circulation
  • ensures that the BP is maintained during diastole so basically act as tubes for filling of blood
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4
Q

what is the pulse pressure

A

difference between SP and DP (SP-DP)

- both pressures creates the pulse pressure wave starting from DP at 80mmHg to SP at 120mmHg

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5
Q

how to work out mean ABP

A

((SP-DP)/3) +DP

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6
Q

what happens to the aortic wall during systole and diastole

A
  • during systole, the wall distends to accommodate the blood flow so the energy converted to elastic energy
  • the aortic wall recoils during diastile to propel the blood forward, energy is then released
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7
Q

why does the pressure wave drop as it travels from aorta all the way to veins

A
  • due to diff R in the diff vessels

- the pressure waves decreases as it moves away from the origin

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8
Q

describe the effect of age on pulse pressure

A

the elastin degenerates and the collagen becomes more prominent so the arteries stiffen

  • leads to increases SP and decreased DP
  • the pressure wave becomes longer in height
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9
Q

what factors determine the ABP (driving force for blood flow)

A
  • blood vol in the arterial system (CO)

- resistance to the blood flow (TPR)

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10
Q

how to work out ABP (NOT mean ABP)

A

CO X TPR

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11
Q

factors determining SP

A
  • SV
  • aortic distensibility
  • ejection vel
  • DP of the previous beat
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12
Q

what factors determines DP

A

-by the arteroilar R and HR

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13
Q

what factors determine the resistance to the blood flow

A
  • vessel length
  • blood viscosity
  • radius
  • leading to poiseuille’s eqn
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14
Q

what happens to the flow when there’s vasodilation

A
  • increases the flow
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15
Q

what happens to the flow when there’s vasoconstriction

A

-decreases the flow

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16
Q

what factors can control the vasodilation or constriction of the arterioles

A
  • endothelial factors
  • local mechanisms
  • central neural mechanisms
  • hormonal mechanisms
17
Q

describe how endothelial factors have an effect on vasodilation or vasoconstriction

A

vasodilation - NO produced to increase calcium levels

vasoconstriction - endothelins produced decrease Ca levels

18
Q

what central neural mechanisms there

A

increased SNS- vasocon (NA acting alpha receptors )
decreases SNS - vasodil (NA acting on beta receptors )
normal tone- some degree of vasocon

19
Q

what hormonal mechanisms are there

A
  • adrenaline increase vasocon and resistance
  • ADH increases vasocon
  • angiotension 2 increase vasocon