L81- Sven psychostim misuse Flashcards
how many subunits does the acetylcholinergic receptor have? what activates it?
at least 12 (highlighted in red)
nicotine activates
2 important structures in the mesolimbic system for dopamine
nucleus accumbens and ventral tegmental area
what are the structural similarities between nicotine and ACh
charged amino groups and hydrogen bond acceptor groups
T or F: nicotine is membrane penetrable at physiological pH (making it a weak base)
true
T or F: Acetylcholinesterase can also degrade nicotine due to similarity in structure
no, dumbass
T or F: ACh has a longer doa than nicotine
also no
partial agonist therapy:
highly ________
varenicline______ _____ increases quit rate success (weird card sorry)
addictive
partial agonist
MOA of cocaine
antagonist of amine transporters (DAT, SERT, NERT)
order of antagonism by receptor affinity for cocaine
(its dat, sert, and nert)
dat>sert>nert
Cocaine:
- Prevents DA _____
- Increases __ concentration
- increases duration of __ action
reuptake
DA
DA
T or F: Amphetamines/bath salts/ecstasy push out DA from vesicles
true
what is trace amine-associated receptor? what activates it?
it phosphorylates DAT and induces reverse transport function. activated by meth/ecstasy/bath salts
clinical effect of meth abuse:
Neurologic (2)
delirium and tremor
clinical effect of meth abuse:
psych (5)
anxiety, paranoia, hallucinations, delusions, repetitive behavior
clinical effect of meth abuse:
ENT (1)
profuse dental decay
