L71 Barker- Pathophys of pain Flashcards
chronic pain means it has lasted at least how long
3 months
4 temporal features of pain
onset, duration, course, pattern
T or F: pain is an emotion that impacts mood
true
Temperature sensitive channel involved in pain signaling
transient receptor potential cation channel (TRP)
Heat sensitive
A. TRPV (vanniloid)
B. TRPM (Melastatin)
A
Cold sensitive
A. TRPV (Vanniloid)
B. TRPM (Melastatin)
B
Acid sensitive channel involved in pain signaling
Acid sensing ion channel (ASIC)
What is the acid sensing ion channel (ASIC) activated by? What happens after?
H+, conducts Na+ -> feel pain
2 compunds listed under chemical irritant sensitive channel involved in pain signaling
histamine
bradykinin
what are the three different pain fibers that transduce different pain signals?
Abeta-fibers
Adelta-fibers
C-fibers
Non-noxious (touch, pressure)
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers
A
Innervate the skin
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers
A
“faster” (35-75 m/s)
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers
A
Pain, cold
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers
B
Myelinated
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers
B
“fast” 2-35 m/s
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers
B
“first pain” reflex arc. Sharp/prickly
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers
B
Pain, temp, touch, pressure, itch (polymodal)
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers
C
Unmyelinated
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers
C
Slow (0.5-2 m/s)
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers
C
“second pain” Dull/aching
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers
C
what plays an important role in heightening pain responding? (weird wording barker)
Substance P*
Substance P: ****
-(Vasodilation or Vasoconstriction)
- Degranulation of _____ cells
- Release of ______
- ________ and prostagandins
Vasodilation
mast
histamine
inflammation
T or F: Substance P increases expression of pain receptors (sensitization)
tru
Neuropathic pain sensitization:
When substance P binds NK1, what effect does it have on AMPA and NMDA?
increased expression and sensitivity of both
PLC -> PKC in what type of pain sensitization
neuropathic
T or F: There is a low expression of opioid receptors in the brain stem along the descending pathway
False, high expression
what is the important receptor to think of when thinking of opioids and the brain
mu
