L 82- Sven weed Flashcards
difference between hemp and marijuana
hemp contains 0.3% or less of THC while weed usually has 15-20%
congress passes marijuana tax act
A. 1937
B. 1996
C. 2013
a
cali passes prop.215 becoming first legal medical weed state
A. 1937
B. 1996
C. 2013
b
cole meme creates hands-off policy for legal medical weed states
A. 1937
B. 1996
C. 2013
c
what year allowed hemp to be cultivated for research purposes
2014
what year was the farm bill passed that federally legalized hemp and hemp derived products like CBD
2018
4 categories involved in acute cannabis intoxication
perceptual
physical
affective
cognitive
what are the 2 receptors that we care about in the endocannabinoid system (ECS)
CB1 and CB2
what are the two ligands in the endocannabinoid system (ECS) that we care about
Anandamide (AEA) and 2-AG
what is the 1 transporter we care about in the endocannabinoid system (ECS)
EMT - endocannabinoid membrane transporter
3 enzymes that we care about in the ECS
- fatty acid amide hydrolase (FAAH)
- mono-glycerol lipase (MAGL)
- diacylglycerol lipase (DAG)
T or F: endocannabinoids and phytocannabinoids are considered retrograde regulators of neurotransmission
true
T or F: endocannabinoids inhibit release of GABA and glutamine
true
THC is what kind of agonist at CB1R?
partial
what kind of agonists are synthetic cannabinoids at the CB1R?
full agonists
ask someone what to know from slide 17 thats weird
okay i might who knows
T or F: CB1 expression in the brain is lower than CB2
false, CB1 is higher
low levels of CB1 (i think idk this is slide 18 if anyone wants to correct me) can lead to what
respiratory depression/coma
T or F: CB2 is expressed more in the periphery than CB1
true
Lymphocytes -> B-cells and T-cells
A. CB2
B. CB1
A
Liver -> increase lipogenesis, upregulated in liver fibrosis
A. CB2
B. CB1
B
what is significant with marinol (dronabinol) from the slide?
its an fda approved weed drug in sesame oil *
what are the 2 fda approved weed drugs
marinol (dronabinol)
Nabilone (cesamet)
it is estimated that what percentage of people using cannabis will develop cannabis use disorder?
10%
what is one way to decide who might be at a higher risk of developing cannabis use disorder?
nothing, there is no way, no way in hell
cannabis use at or beow what age leads to a higher risk of developing schizo?
15
what are the 2 key determinants to risk factors and pathway to psychosis in dirty little weed smokers
age of use onset and potency **
4 tx options for cannabinoid hyperemesis syndrome *
cannabis cessation
benzos
haloperidol
capsaicin cream on abdomen
diagnostic criteria for cannabinoid hyperemesis syndrome
- cyclic vomiting/ab pain
- presentation after prolonged use
- relief by sustained cessation
- may be associated with pathological bathing (what the fuck?)
