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PHRM 845 > L45 Pharm tx of neurocog disorders: dementia > Flashcards

L45 Pharm tx of neurocog disorders: dementia Flashcards

1
Q

3 diseases that fall under either major or mild NDCs

A

AD
Lewy Body Disease
Vascular dementia

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2
Q

4 most frequent drug induced pd classes

A
  • skeletal muscle relaxants
  • tricyclic antidepressants
  • bladder antispasmodics
  • antihistaminse
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3
Q

what scale is used to access cognitive functioning and is 0-30 points

A

MMSE, 30 points is the best by the way, 3-4 points a year over time for dementia pts

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4
Q

better differentiates mild cognitive impairment than MMSE

A

MoCA

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5
Q

options for tx in dementia (2 classes)

A

Cholinesterase inhibitors
NMDA receptor antagonist

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6
Q

NMDA receptor antagonists are only FDA-approved in what level(s) of dementia

A

moderate to severe

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7
Q

dosing for donepezil

A

initiate 5 mg qhs qs, increase 10 mg qhs qd after 4-6 weeks

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8
Q

donepezil side effects
(6 of them)

A
  • Gi bleeding
  • N/V/D
  • Bradycardia
  • Syncope
  • insomnia
  • weight loss
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9
Q

which of the following is a P450 and 3A3/4 substrate
A. Donepezil (Aricept)
B. Galantine (Razadyne)
C. Rivastigmine (Exelon)

A

A. Donepezil (Aricept)
B. Galantine (Razadyne)

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10
Q

Galantamine (Razadyne) dosing

A

Initiate 4 mg bid for 4 weeks with breakfast and dinner

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11
Q

Side effects of Galantamine
(6 of them)

A
  • Gi bleeding
  • weight loss
  • N/V/D
  • Bradycardia
  • syncope
  • insomnia
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12
Q

doses of galantamine above 16mg/day are not recommended when

A

Renal/hepatic impairment

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13
Q

Rivastigmine dosing regimen (how many times a day)

A

1.5 mg bid

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14
Q

Taking rivastigmine with meals has what effect?

A

minimize GI effects

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15
Q

What can lead to toxicity with rivastigmine? **

A

not removing previous patch every day (N/V/D) (SIGNIFICANT)*

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16
Q

which of the following is associated with esophageal rupture?
A. Donepezil (Aricept)
B. Galantine (Razadyne)
C. Rivastigmine (Exelon)

A

C. rivastigmine (Exelon)

17
Q

side effect of aducanumab (Aduhelm)

A

ARIA (Amyloid-Related Imaging Abnormalities): up to 40% requires MRI of brain within one year of starting tx, then before 7th and 12th doses (wtf does this mean)

18
Q

Lecanemab (Leqembi) side effect

A

ARIA: Up to 30% requires MRI of brain within one year of starting tx, then before 5th, 7th, and 14th doses.

19
Q

eligibility for Aducanumab and Lecanemab

A

requires presence of amyloid beta pathology prior to initiating tx

20
Q

bolded option on the agitation interventions slide

A

introduce distraction techniques, turn attention to something pleasant

PHRM 845 (34 decks)

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