L78 Flashcards
What is exanthem?
Rash on skin
Vs. enanthem = rash on mucous membrane
Big 5 childhood diseases that cause rash
Measles Strep pyogenes Rubella Parvo - erythema infectiosum Roseola (HHV 6)
Symptoms of measles
3 Cs + K Conjunctivitis Cough Coryza = running nose Koplic spots = enanthem rash in the mouth w/ grey middle
Describe the measles rash: appearance, timing
= Rubeola Develops after Koplic spots Starts on face Progresses centrally Moves to periphery & toes
Geographic tip offs for measles
California
Switzerland
Measles incubation
1 up to 2 wks
Day 10 - fever
Day 14 - rash
Infectious before symptoms start during this incubation period
Measles transmission
Air-born
Kids in school
Diagnose measles
- Clinical
2. Serum testing - IgM/G - watch out for false +/-
What tissue does measles infect?
Respiratory epithelium –> LN
Which immune system is important for measles resolution?
Cellular
Measles genome
(-) ssRNA
Enveloped
Labile
What cell types does measles infect during primary viremia?
T cells! Same time once penetrated resp epi
Causes temp immune suppression that is definitely noticeable
- Pna
What CNS disease might result from measles? When might this present?
Encephalitis
Acute or sub-acute years later!
What nutrition deficiency would make measles worse?
Vit A def
When do you give the measles vaccine?
9mo-1 year
Live, attenuated vaccine - therefore babies who have mom’s Abs might not have right response