Hepatitis Flashcards
How is Hep A transmitted?
Fecal-oral
How is Hep B transmitted?
Blood - IVDU and needles
Sexual
Mom –> fetus
How is Hep C transmitted?
Blood - IVDU and needles
Sex - more unlikely
How is Hep D transmitted?
Blood
Same as B since present together
How is E transmitted?
Fecal-oral
What does high transaminases (ALT/AST) indicate?
Hepato-cellular injury, necrosis, death
What is the likely outcome of Hep A infection in adults?
Fully recovery
No chronic damage or cancer
What is the likely disease process and outcome of Hep A infection in kids?
Less severe disease - likely asymptomatic
What is the disease outcome of Hep B infection in adults?
Highest chance for full recovery
Chance of:
- Chronic hepatitis
- Higher risk of fulminant (sudden onsent) hepatitis
What complication is associated with Hep B in kids?
Higher risk of chronic hepatitis
But again, disease is likely to be less severe in kids
What is the Hep A vaccine?
Killed virus
What is the Hep B vaccine?
Recombinant surface antigen
Which has the highest risk of transmission via needle stick: HIV, Hep B, or Hep C?
Hep B!!
What do you give for Hep B prophylaxis?
Hyper immune gloublin + vaccine
Hep C prophylaxis
IFNa if acute infection develops
Otherwise monitor
Causes of cirrhosis
Alcohol
Hep B & C
Congenital
Toxins/meds
Treat Hep B
RT inhibitors: tenofovir
Pegylated IFNa
Treat Hep C
IFNa + ribavirin + protease inhibitor (telaprevir or boceprevir)
What stage of infection is Hep C Ab neg but RNA present?
Acute
What stage of infection is Hep Ab neg and RNA neg?
Not infected!!
What stage of infection is Hep C Ab + RNA +?
Active chronic?
What stage of infection is Hep C Ab+ RNA -?
Previous/resolved/not ongoing Hep C infection
Which Hep C genotype is most common throughout the US?
Type 1a
