L77

Question 1

Ebola’s non-human reservoir

Answer 1

Bats

Question 2

Will Ebola be eradicated?

Answer 2

No - can’t kill or immunize all the bats

Question 3

Ebola transmission

Answer 3

P2P - blood highest risk

Air - low risk

Question 4

How do you make Ebola self-limiting?

Answer 4

Isolation protocols

Question 5

What cells does Ebola initially infect?

Answer 5

DCs

Macrophages

Question 6

When do infected people begin to be able to actively transmit Ebola?

Answer 6

Once symptomatic

Until symptoms, you can’t even find the virus in the blood by PCR

Question 7

What dets worse prognosis with Ebola

Answer 7

Higher viral load

Question 8

What kind of disease is Ebola? What is the first symptom? What is the gimme symptom?

Answer 8

Viral hemorrhagic fever
Fever = most common
Bleeding anywhere = hallmark
- Not common
- Happens in late stages if at all 
- Not really the life threatening aspect

Question 9

Explain IFN therapy.

Answer 9

Infected cells naturally produce IFN to induce an anti-viral state in neighboring cells to prevent infection
If you give IFN as a med - you’d make host cells inhospitable to infection

Question 10

IFN mechanism of preventing infection

Answer 10

Viral mRNA degradation

X ribosome assembly

Question 11

Explain why IFN isn’t the idea therapy

Answer 11

Some viruses make IFN antagonists (Ebola)

Dosing IFN has negative SE - changes natural immune state + fevers