L7 - Anti-inflammatory & Immunosupressant drugs I Flashcards
Types of NSAIDs
Aspirin - Acetlysalicylic acid
Paracetamol - Acetomenaphyn
Ibrprophen
What do NSAIDs inhibit?
the production of inflammatory mediators, eg, prostaglandins and thromboxanes.
Being made by one cell and affecting many cells makes a cell a …
Paracrine mediator
What are Cycloxygenases (COX)?
Enzymes that activate inflammatory medaitors.
How to NSAIDs stop the action of prostaglandins?
By targeting the cycloxygenases
What is protaglandin F important for?
The initiation of labour
What is prostaglandin G important for?
platelet aggregation, also a vasodilator
What is prostaglandin E2 improtant for?
A vasodilator, also a hyperalgesic
How do NSAIDs work?
- Anti-inflammatory - decreases vasodilation and in turn odemas.
- Analgesic - reduces pain by decreasing production of prostaglandins in damages and inflamed tissue, sensetising nociceptors to inflammatory mediators.
- Antipyretic - lowers temperature, thermostat in hypothalamus activated via IL1 induces COX2 production.
What are cyclooxygenases (COXs) made out of?
2 identical subunits, each with 2 catalytic sites
COX1
constitutive expression, platlets, stomach, kidney, colon.
COX2
Inducible expression
COX3
In CNS target for paracetamol
Why does COX2 allow more drugs through than COX1?
COX2 has a wider channel
Why could NSAIDs cause stamach ulcers?
Because they destroy protaglandins and prostaglandins play a key role in the mucus layer of the GI tract.
