L11 - Drug Development II Flashcards
What is a small molecule?
- molecule with low molecular weight.
- Chemically synthesised
- Well defined structure
What is a biological molecule?
- molecule with a high molecular weight
- derived from living organisms
- With a large and complex structure
What are biopharmaceuticals?
Products in which the active substance is produced by, or extracted from, a biological source.
What is a surrogate molecule?
Also known as homologous proteins are proteins that recognize the target in an animal model, that is analogous to the human target recognized by the clinical product.
What is immunopharmacology?
- Drug action on the immune system.
- Where the immune system is the target of
the therapeutic effect.
What is immunotoxicology?
The study of immune system dysfunction that can result from drugs that alter the immune system and affect human health.
What happens in phase 1 studies?
- First stage of clinical testing and is often also referred to as First in Man.
- To test if the drug is safe in humans and
to check for signs of any potentially
dangerous effects,
TGN1412 (or CD28-SuperMAB)
An immunomodulatory drug which was withdrawn from development after inducing severe inflammatory reactions in the first-in-man study.
What is immunotherapy?
A form of cancer treatment that uses the immune system to attack cancer cells.
What are Checkpoint Inhibitors?
Substances that work by releasing a natural brake on your immune system so that immune cells called T cells recognize and attack tumors.
What is CAR T Cell Therapy?
Chimeric antigen receptor (CAR) T cell therapyis an approach in which scientists genetically engineer a patient’s own immune cells to make a new protein
