L4 - Drug Receptor Theory II - Agonists Flashcards
1
Q
What is activation governed by?
A
Efficacy
2
Q
What is the EC 50
A
Effective concentration giving 50% of maximal response.
3
Q
What is “receptor reserve”
A
not 100% of receptor occupied to maximal response
(some tissues cna get max response with 5% occupancy)
4
Q
What does the potency of an agonist depend on?
A
The affinity
5
Q
What does a partial agonist do in the presence of a agonist?
A
Acts as an antagonist and causes a shift to the right in the curve
6
Q
What is efficacy?
A
a measure of a single agonist-receptor complex’s ability of generate a response.
