Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immune system > L7 > Flashcards

L7 Flashcards

1
Q

What does B cells recognise?

A

Native antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Where do B cells fully develop?

A

In bone Marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How are BCR’s anchored onto cell surface?

A

Transmembrane Domain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the 3 functions of antibodies?

A

Neutralisation
Opsonisation
Complement activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is antibody neutralisation?

A

Antibody binds to virus and blocks interactions between host cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is antibody neutralisation?

A

Antibody binds to virus and blocks interactions between host cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is antibody opsonisation?

A

Antibody labels bacteria, making phagocytes eat it

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is antibody complement?

A

Antibody activates complement which forms membrane attack complex (pores into bacteria)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

IgG - Distribution, Function

A

Most abundant IgG class in blood

Opsonises / neutralises

only Ig class that crosses placenta and provides passive immunite

targets virus and bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

IgA - Ditribution and function

A

Present in secretions eg (tears and saliva) and monomeric form in blood, Breast milk

Defence of Mucous membranes eg gut

Pressent in breast milk which confers passive immunity to nursing infant

targets virus and bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

IgM

A

First Ig class produced after initial exposure to antigen

expressed on naive B cells

Effective in activating complement

targets extracellular bacteria and acts as antigen receptor (BCR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

IgE

A

Present in blood at low concentrations

Immunity to multicellular parasites

Activates mast cells for parasite immunity and the allergic response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

IgD

A

Expressed on naive B cells

Together with IgM acts and BCR

unknown function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the two antibodys expressed on newly matured B cell

A

IgM and IgD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

B cell memory Cells

A

Expresses Antibody as BCR but do not secrete it

Respond rapidly to antigen encounter and become plasma cells

17
Q

What is primary immune response?

A

7-14 days before sufficient antibody is produced to eliminate pathogen

Relatively low amount of antibody produced, mainly IgM

18
Q

What is Secondary immune response

A

Basis of success of vaccination

Relies on memory B cells

Fast (2-3 days) sufficent antibodies produced mainly IgG

Class switches to defend against mucousal (IgA)
Parasites (IgE)

19
Q
A
20
Q

What are the two antibody’s in providing passive immunity to infants

A

IgG and IgA

Immune system (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions