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BMS382 - Stem cell biology > L5 - iPSC > Flashcards

L5 - iPSC Flashcards

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1
Q

What are the 4 PP factors?

A

Oct3/4, Sox2, c-myc, Klf4

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2
Q

What are the thomsen PP factors?

A

Oct4, sox2, nanog, Lin28

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3
Q

How can we use human iPSC?

A

Cellular studies - study disease in vitro
Transplantation studies - study disease in vivo
Drug/genetic screens

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4
Q

What are some issues with hESCs?

A

Genomic instability
Need high constant supply of high quality embryos
Potential for tumour formation
Ethically contentious

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BMS382 - Stem cell biology (10 decks)

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