L3. Haematopoetic stem cells

Question 1

What is haematopoesis?

Answer 1

Formation of blood cellualr components, derived from haematopoetic stem cells.

Question 2

What is a haematopoetic stem cell?

Answer 2

Type of stemcell found in the bone marrow, derived from the mesoderm (an embryonic germ layer)

Question 3

What 2 progenitor cells can a haematopoetic stem cell turn into?

Answer 3

1) Myeloid progenitor cell

2) Lymphoid progenitor cell

Question 4

What 4 types of cells can myeloid progenitor cells differentiate into?

Answer 4

1) Megakaryoblast
2) Proerythroblast
3) Myoblast
4) Monoblast

Question 5

What does a megakaryoblast differentiate into?

Answer 5

Megakaryocyte –> platelets

Question 6

What does a proerythroblast differentiate into?

Answer 6

Reticulocyte –> Erythroctyte

Question 7

What does a myoblast differentiate into?

Answer 7

Basophil, neutrophil, eosinophil

Question 8

What does a monoblast differentiate into?

Answer 8

Monocyte

Question 9

What can the lymphoid progenitor cell differentiate into?

Answer 9

Lymphoblast –> NK cell, T and B cells

Question 10

What is a characteristic of a haematopoetic stem cell?

Answer 10

They’re capable of self-renewal

Can differentiate into all it’s progenitors.

Question 11

What are progenitor cells capable of?

Answer 11

Proliferation & differentiation