L2. Rh blood group system Flashcards
1
Q
What are the two genes in the Rh blood system?
A
RhD
RhCcEe
2
Q
What type of proteins are Rh?
A
Multipass.
3
Q
What are the antigens for Rh?
A
D, C, c, E, e
4
Q
What is Anti-D AB responsible for?
A
Responsible for most clinical problems, and is not occurring as often as RhD+
5
Q
What happens when mother is RhD- and child RhD+?
A
RhD+ RBCs from fetus cross to maternal circulation. Anti-Rhesus are immune ABs, can cross placenta, coat RhD+ fetal RBC, can result in reticuloendothelial destruction of RBC by macrophages.
6
Q
How is hemolytic disease of newborn prevented?
A
Mother receives immunoporhylaxis w/ Anti-RhD at 30 weeks and after birth.
Anti-RhD ABs mop any RhD+ fetus cell in mother, so no immune response is generated.
