L2. ABO's Flashcards
What is apheresis?
Technique where only the necessary blood component is collected, plasma or single donor platelets. Other components are delivered back into the donor.
What is the frequency of ABs in A B O systems?
Almost universal
What is the frequency of ABs in Rh systems?
Common
Which causes haemolytic disease of the newborn?
ABO mildly, and Rh.
What are the multi-pass proteins with 6 transmembranes?
Rh
Diego
Kidd
What are multi-pass proteins with 7 transmembranes?
Duffy
What are the three types of proteins that carry blood group antigens?
1) Single pass proteins
2) Multi-pass proteins
2) GPI-Linked protein.
What are the single pass proteins?
MNS, Kell
What are ABO antigens?
Polysaccharides.
Proteins encoded by A, B, O alleles are glycosyltransferasses.
What does the O group have?
The H-antigen with gal-fuc.
No additional polysaccharide.
Where does A antigen consist of?
Gal-fuc-galnac. Extra N-acetyl galactosamine to H-antigen
What does the B antigen consist of?
gal-fuc-gal. Extra galactose to H-antigen.
What do people with hh-antigen, or Bombay blood group, not have?
lacks H-antigen. Can’t accept blood from any of the groups because there’s a naturally occurring AB against galactose-fructose/H-antigen.
