L3. Bone marrow

Question 1

How many cells in the bone marrow are HSCs?

Answer 1

1 in 20 million

Question 2

What is the state of HSC’s in the bonemarrow?

Answer 2

Most are dormant (there but not in cell cycle), only a few % are active in the cell cycle.

Question 3

Name examples how the stem cell can be in contact with cells, such as macrophages, fibroblast, mesenchymal cells.

Answer 3

Either cell-cell contact, OR:
HSC has either ligand or growth factor receptor (glycoproteins) that recognises adhesion molecules or growth factors on the type of cells .

Question 4

Name examples of what the mesenchymal cells give rise to

Answer 4

Gives rise to bone cells, connective tissue e.g.