L25- RTI IX Flashcards
Ornithosis, formerly called (1), is caused by (2) which is a (3) type microbe of (4) size.
1- psittacosis, parrot fever
2- chlamydophila psittaci
3- parasite of eukaryotic cells
4- 0.45 µm
Chlamyodophila psittaci:
- (1) location during infection
- Gram(+/-)
- (3) are the reservoirs
- (4) are the forms
1- obligate intracellular
2- gram- (not staining wise, but yes structurally)
3- birds
4- EB (infectious), RB (replicative) forms
Chlamyodophila psittaci:
- outer cell wall resembles (1) and contains (2), but lacks (3)
- its shape is considered (4)
- (5) is the major component of the outer cell wall is common and unique to each chlamydia species
1- gram- 2- weakly endotoxic LPS 3- peptidoglycan 4- round with thin periplasmic space 5- MOMP- major outer membrane protein
briefly describe the life cycle of chlamyodophila psittaci
1) EB attaches to target cell (via microvilli)
2) EB endocytosis and prevents fusion with lysosome
3) EB –> RB
4) RB replication via binary fission
5) RB –> EB (inclusion bodies contain both)
6) lysis of cells and inclusion bodies for release of virus
in chlamyodophila psittaci life cycle, it takes (1) time for EBs to penetrate and becomes active RB and then takes (2) amount of time to reform EBs
1- 6-8 hrs post-penetration (EB –> RBs)
2- 18-24 hrs later (RB –> EB)
Clamyodophila psittaci:
- (1) is the method of transmission
- spreads to (2) parts of liver, kidneys to cause (3)
-(4) list the many respiratory effects
1- urine or respiratory droplets of birds
2- reticuloendothelial system
3- necrosis
4:
- lymphacytic inflammation of alveoli
- edema, thickening of alveolar wall
- infiltration of macrophages, necrosis and occasional hemorrhages
- mucus plugs bronchioles –> cyanosis, anoxia
what are the high risk factors associates with ornithosis
(bird exposure)
- vets, zookeepers
- pet shop owners
- employees of poultry processing plants
Ornithosis / chlamydophila psittaci:
- (1) incubation period
- (2) initial sxs
- (3) pulmonary sxs
- (4) CNS sxs
- (5) GI sxs
- (6) other possible developments
1- 5-14 days
2- HA, high fever, chills, myalgia
3- nonproductive cough, consolidation
4- (common) encephalitis, convulsions, coma, death
5- n/v/d
6- hepatosplenomegaly, follicular keratoconjunctivitis
Ornithosis:
- (1) Dx
- (2) Tx
- (3) additional prevention strategies
1- serology (maybe PCR)
2- antibiotics + patient isolation
3- (no vaccines available) antibiotic treatment for infected birds
HPS, aka (1), is commonly associated with (2) vector. It is characterized by (3) symptoms leading into (4) symptoms, and then finally (5).
1- hantavirus pulmonary syndrome 2- rodent 3- febrile prodrome 4- acute respiratory failure 5- death due to circulatory collapse
HPS is caused by viruses in the (1) family, (2) virus is most common. Most cases in the US happen in (3) region.
1- bunyaviridae family (hantavirus)
2- sin nombre virus
3- west of the Mississippi River (>96% of cases)
Bunyaviridae / SNV are (non-/enveloped) (+/-) (ss/ds) (RNA/DNA) with a (5) shape
(sin nombre virus)
enveloped (lipids + 2 major glycoproteins) (-) sense ssRNA, spherical
(1) is the main risk factor for HPS, and usually affects people in (2) areas, where (3) are potential sites.
Hantaviruses can also cause (4) in addition to HPS.
1- rodent infestation
2- rural areas
3- peridomestic sites: barns, outbuildings, sheds
4- HFRS- hemorrhagic fever with renal syndrome
SNV is transmitted via (1), primarily in (2) season.
(sin nombre virus)
1- airborne transmission in rodent droppings (urine, feces, saliva)
2- fall
HPS clinical features:
- (1) incubation period
- (2) 1st phase
- (3) 2nd phase
- (4) 3rd phase
- (5) mortality rate
1- 1-8 wks
2- Prodromal (3-5 days): viral illness of fever, HA, myalgia, v/d (similar to viral gastroenteritis)
3- Cardiopulmonary (24-48hrs): dyspnea, dry cough, pulmonary edema, circulatory collapse
4- Convalescent: significant diuresis, sxs improve and complete recovery over wks
5- 50% fatality rate