L2- Pulmonary Pathology I Flashcards
Define the following:
- TV
- IRV
- ERV
- RV
Tidal Vol.: volume of air inhaled and exhaled with normal respiration
Inspiratory Reserve Vol.: volume of air that can be inhaled beyond normal inspiration
Expiratory Reserve Vol.: volume of air that can be exhaled beyond normal expiration
Residual Vol.: left over air volume after maximal exhalation
Define the following:
- TLC
- VC
- IC
- FRC
Total Lung Capacity: maximal lung volume after maximal inhalation
Vital Capacity: maximal lung volume that can be inhaled/exhaled (TLC - RV = IRV + ERV + TV)
Inspiratory Capacity: maximal air volume that can be inhaled following normal expiration (TV + IRV)
Functional Residual Capacity: lung volume after normal expiration (ERV + RV)
Define the following:
- FVC
- FVC1
- FEF
Forced Vital Capacity: volume of air exhaled with force following maximal inhalation
FVC-1: volume of air exhaled with force in first second following maximal inhalation
Forced Expiratory Flow (25%-75%): measure of airflow midway through expiration (middle half)
Describe how the following change in Restrictive Lung Disease:
- FEV1/FVC
- FEV1
- FVC
- TLC
- FEV1/FVC: normal or inc (>80%)
- FEV1: normal or slightly dec
- FVC: dec
- TLC: dec
Describe how the following change in Obstructive Lung Disease:
- FEV1/FVC
- FEV1
- FVC
- TLC
- FEV1/FVC: dec (<70%)
- FEV1: dec (significant)
- FVC: dec or normal
- TLC: inc or normal
list the 4 types of laboratory tests conducted in the respiratory system
- Sputum analysis: cells, microbiology
- Arterial blood gases (pCO2, pO2)
- Pleural fluid
- Blood Culture
describe the goal or types of tests conducted in sputum analysis
Cell analysis: WBCs, RBCs, malignant cells
Microbiological Studies:
- bacteria (staining, culture, AB resistant)
- fungal (KOH, culture)
- viral (PCR, DNA, culture)
- NAAT (nucleic acid amplification testing)
what are the blood gas changes seen in lung diseases and why are they monitored
- pCO2: looking for INCreases
- pO2: looking for DECreases
-the quantity of changes determines the severity of the disease progression
describe how pleural fluid is studied for lung diseases
-used as a therapeutic or diagnostic technique
i) Cell Count: HF (dec to normal) vs Infection (inc)
ii) Malignancy: primary vs secondary
list the techniques or procedures used to acquire lung sample for cytology (hint- 9)
- bronchial washings (inject slime and aspirate it out)
- bronchial brushing (scraping lesion)
- TBNA, transbronchial needle aspiration
- TTNA, transthoracic needle aspiration
- EBUS-FNA, endobronchial ultrasound-guided fine needle aspiration
-navigational bronchoscopy
- bronchoscopic biopsy: transbronchial, endobronchial
- pleuroscopic biopsy
-Surgical biopsy / resection: VATS (video assisted transthoracic) biopsy or Open biopsy
foreign objects that are accidentally inhaled will generally go into the (R/L) lung because of (2)
R lung- the R main bronchus is shorter and more vertical than the L
Respiratory Zone function, (1)
Conducting Zone function, (2)
1- gas exchange
2- carry, warm, filter, humidify air
list the components of the Bronchial Walls (histology)
[conducting zone only- no gas exchange] (inside to outside) 1) Epithelium: ciliated columnar cells, goblet cells, basal cells, neuroendocrine cells 2) Basement Membrane 3) Smooth Muscle 4) Seromucinous Glands 5) Cartilage 6) Vasculature and Lymphatics
list the components of the Bronchiolar Walls (histology)
[conducting zone until terminal bronchioles –> respiratory zone and respiratory bronchioles]
(inside to outside)
1) Epithelium: ciliated columnar cells, Clara cells
2) Basement Membrane
3) Smooth Muscle
4) Vasculature and Lymphatics
compare the epithelium of Bronchi and Bronchioles
Bronchi: ciliated columnar cells, goblet cells, basal cells, neuroendocrine cells
Bronchioles: ciliated columnar cells, Clara cells
describe the histology of alveoli
(inside to outside)
1) epithelium: type I/II pneumocytes
2) alveolar macrophages
3) interstitium
4) capillaries (endothelial cells)
The alveolar epithelium is mostly type (I/II) pneumocytes.
- type I function, (2)
- type II function, (3)
1- type I, 95%
2- gas exchange
3- surfactant production, alveolar epithelium repair (generates type I and II pneumocytes)