L220/L221

Question 1

Parkinsons diseases is a result of

Answer 1

Degeneration of dopaminergic neurons from substantia nigra to striatum

Question 2

Importance of carbidopa

Answer 2

Dopa decarboxylase inhibitor..prevents conversion of L-dopa into dopamine
Results in more BBB crossing and less nausea

Question 3

Metabolic enzyme inhibitors for parkinsons

Answer 3

MAO

COMT

Question 4

Anti-siezure drug actions

Answer 4

Block high frequency firing
Potential effects of GABA
Block t type Ca channels
Block voltage gated Ca channels
Blockage of NMDA receptors

Question 5

Mechanisms of GABA potentiation

Answer 5

Inhibition of GABA transaminase
Inhibtion of GABA uptake
Facilitation of Cl channel opening

Question 6

Cells that uptake GABA

Answer 6

Glia cells

Question 7

Used in emergency treatment of siezures

Answer 7

Benzos by facilitation of Cl channel opening

Question 8

Progression of CNS effects of barbiturates and benzos

Answer 8

Anti-anxiety
Sedation (relaxation W/O loss of consciousness)
Hypnosis (impaired responsiveness)
Anesthesia (no possibility of arousal)
Resp. failure

Question 9

GABA A vs GABA B Receptors

Answer 9

GABA A receptor: ligand gated
GABA B receptor: G protein coupled
-activate K channels via GbetaGgamma
-diminish Ca entry into cells

Question 10

Barbiturates vs Benzo

Answer 10

Barb: increase duration of GABA-A channel
Benzo: increase frequency of GABA A channel

Question 11

What is the most important difference in benzos

Answer 11

pharmacokinetic behavior

Question 12

Flumazenil

Answer 12

used to manage benzo overdose