L219 CNS Pharm Flashcards
Action potential initiation is affected by
Number and types of postsynaptic receptors
Synchrony of incoming signals
Frequency of incoming signals
Neurotransmitter vs neuromodulator
Transmitter: opens channel
Modulator: activate G protein receptor
How many subtypes of glutamate are there
8
What do most of the glutamate subtypes do
inhibit adenylate cyclase
How do GABA receptors work
Activate Cl channels and cause hyperpolarization
How do glycine receptors work
Activate Cl channels and cause hyperpolarization
THC potentiates this
Szhizophrenia delusions and hallucinations due to
Excess dopamine (orveractivity of mesolimbic pathway)
Szhizophrenia catatonia due to
prefrontal pathologies (mesocortical pathway dysfunction)
Dopamine receptors categorization and what they do
D1-like: Enhance cAMP thru Galpha-s
-D1, D5
D2-like: Diminish cAMP thru Galpha-i
-D2, D3, D4
Schizophrenia glutamate hypothesis
Hypofunction of NMDA receptors
Clozapine
Helps with negative symptoms by activation of glycine modulatory site on NMDA receptor (glutamate receptor) (Not a typo)
Which receptors are involved in producing therapeutic and adverse effects of anti-psychotics
Antagonism of D2 and D4 Antagonism of 5HT2A Antagonism of H1 Antagonism of M1 Antagonism of alpha-1 adrenergic
Extrapyramidal side effects and hyperprolactinemia is due to
D2 blockade
Classical vs atypical blcoking
Classical: D2 blockade (affect +), extrapyramidal effects
Atypical: 5HT2, D4, weak D2 (affect + and -), No xtra pyramidal effects
Monoamine hypothesis
depression due to NE and Serotonin
