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AU16 Pharm2 > L22/L24 First half > Flashcards

L22/L24 First half Flashcards

1
Q

TH1 activates..

A

TNF-beta
IFN gamma
Macrophages (cell mediated immunity)

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2
Q

TH2 activates

A

IL4
IL5
IL13
B cells (antibody mediated)

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3
Q

Sequence of events leading to infiltration of eosinophils in the lung

A

Allergen
Mast cell
TH2
Eosinophils

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4
Q

Th1 vs Th2 with pathogens

A

Th1: intracellular: yeast, virus, bacteria, cancer
Th2: extracellular: parasite, bacteria, toxin, allergin

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5
Q

TH2 vs TH17 asthma

Glucocorticoid response

A

Th2: eosinophilic asthma: glucocorticoid responsive
Th17: neutrophilic asthma: glucocorticoid resistant

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6
Q

Chemical responsible for bronchocontriction

A

Leukotriences (1000x more potent than histamine in airway)

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7
Q

Goals of asthma treatment..Prevent…

A

Bronchoconstriction
Inflammation from mucus
Airway remodeling

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8
Q

Asthma vs COPD

A

Childhood vs adult
Allergic response vs change in vagal tone
Symptom free w/ treatment vs partially irreversible
Usually eosinophils vs neutrophils

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9
Q

Pathway of bronchoconstriction

A

Degranulation in mast cells
Cystidinyl leukotrienes
Bonchoconstriction

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10
Q

How do asthma drugs work?

A

Stymie allergic response
Diminish number of immune cells in lung
Alter bronchoconstrictor production
Stop bronchoconstrictors and mucus producers

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11
Q

Enzyme that inhibits MLCK

A

PKA

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12
Q

B2 pathways

A

G protein, AC, cAMP, PKA–X MLCK, Bronchodilation

G protein, AC, cAMP, PKA–>K channels, hyperpolarization–> reduce Ca–X MLCK

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13
Q

Albuterol

A

SABA effective within minutes
Lasts 4-6 hours
GOLD STANDARD

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14
Q

Why are LABAs long acting?

What are they used in conjunction with?

A

Hydrophobic
Corticosteroids
Anticholinergics

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15
Q

Adverse effects of B2 agonists

A

Muscle tremor
Tachycardia
Headache, restlessness

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16
Q

Cortisol on adrenergic receptors

A

Vasoconstriction

Bronchodilation

17
Q

Anti-inflammatory effects of glucocorticoids

A 
Attenuate Leukocyte trafficking
Inhibit apoptosis of Neutrophils
Promote apoptosis of eosinophils
Diminish Mono/macro production
Diminish mast/baso cytokine and degranulation
Upregulate vasodilatory bradykinin

AU16 Pharm2 (8 decks)

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