L22/23 Second half Flashcards

1
Q

Glucocorticoid receptor complex mechanisms

A

Direct activation of gene expression

Direct blocking of NFkB mediated transcription

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2
Q

Annexin A1 in immune system

A

Decrease leukocyte adhesion
Decrease leuko trasmigration
Increase leuko apoptosis
Attenuates Eicosanoid production

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3
Q

How does Annexin inhibit Prostaglandin synthesis

A

Blocks PLA

Blocks COX1,2

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4
Q

GR mediated inhibtion of NFkB mediated transcription

A

Induce transcription of IkB(binds NFkB in cytoplasm) (mech. 1)
Block NFkB mediated transcirption thru chromatin remodeling

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5
Q

Dosage for chronic adrenal insufficiency vs inflammation and immune

A

Chronic: low dose
Inflammation: high dose

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6
Q

Desired features of Inhalational corticosteroids (4)

A

High affinity for GR
Minimal systemic absorp
Serum protein bound
Rapid systemic inactivation

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7
Q

Use of SABA w/ asthma

A

Unless excercise induced or intermittent, SABA less than 3x/week

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8
Q

Use of ICS in treatment of COPD

A

Recommended as additional therapy for patients with exacerbations already taking bronchodilators

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9
Q

Anticholinergics for COPD

A

Antimuscarinic (Atropine)

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10
Q

Blockage of which Muscarinic recceptors lead to bronchodilation?

A

M1

M3

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11
Q

Signaling by muscarinic receptor

A

Increase kinase –>MLC-P

Decrease phosphatase

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12
Q

Only reversible component of COPD

A

ACh mediated boncho-constriction

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13
Q

First line of defense in treating COPD

A

Anti cholinergics (similar to atropine)

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14
Q

Leukotriene biosynthesis

A

Arachidonic acid
–5 lipoxygenase–>
Leukotrienes

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15
Q

Types of mucous glands

A

Anterior serous glands: watery, non viscous

Posterior seromucous glands:Nasal discharge

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16
Q

Treatment for Allergic Rhinitis

A

H1 antagonist
Alpha1 adrenergic agnonist
Intranasal corticosteroids

17
Q

H1
H1/3
H2
H4

A

H1: bonchconstrict, vasodilation
H1/3: sleep/wake, mood
H2: Stomach acid secretion
H4: mast cell chemotaxis