L20- Pharmacy Issues In Pregnancy

Question 1

3 stages of foetal development

Answer 1

Blastocyst formation - 0-16 days after
Organogenesis (cell division,migration,differentiation and death)- 17-60 days after
Histogenesis and functional maturation - 61-full term

Question 2

What happens in each trimester

Answer 2

1st- increased bv,uterine and breast size
2nd- deposition of fat stores
3rd - foetal and placental growth

Question 3

Physiological changes in pregnancy

Answer 3

Increased HR decreased BP
decreased acid secretion and gastric emptying
Decreased bladder capacity and urinary control

Question 4

What does the quantity of drug reaching foetus depend on

Answer 4

Physio chemical characteristics and maternal pharmacokinetic parameters

Question 5

Common issues in pregnancy

Answer 5

Nausea and vomiting
Harmorrhouds
Indigestion
UTI/thrush
Anaemia
Infections
Hypertension
Gestational diabetes
VTE
obstetric cholestasis

Question 6

Hormone which is increased in pregnancy causing sickness

Answer 6

Hcg

Question 8

Teratogenic drugs

Answer 8

Cause malformations in child

Eg anticoagulants, alcohol, chemo, retinoids, anticonvulsants

Question 9

Breastfeeding when on medication

Answer 9

Feed just before taking medication as lipid soluble drugs will be high in conc due to fat content of milk

Question 10

Indigestion in pregnancy

Answer 10

3rd trimester

Question 11

Thrush in pregnancy

Answer 11

Best to refer to gp to prescribe oral treatment

Question 12

UTI in pregnancy

Answer 12

Refer to GP